Impaired metabolic health over-time and high abdominal fat are prospectively associated with high-sensitivity C-reactive protein in children: The IDEFICS study

González-Gil E.M. (Universidad de Zaragoza) ; Moreno L.A. (Universidad de Zaragoza) ; Nappo A. ; Santabárbara J. (Universidad de Zaragoza) ; Wolters M. ; Russo P. ; De Henauw S. ; Veidebaum T. ; Molnar D. ; Hunsberger M. ; Fraterman A. ; Iacoviello L. ; Tornaritis M. ; Ahrens W. ; Bel-Serrat S. ; on behalf the IDEFICS consortium

Resumen: Background: Metabolic risk and inflammatory state have an early life onset and are associated with future diseases. Objectives: To assess the association between metabolic syndrome (MetS) and metabolic health with high-sensitive C-reactive protein (hsCRP), cross-sectionally and longitudinally, in children. Methods: 2913 European children (2-10 years) from eight countries from the IDEFICS study were investigated. Data were collected at baseline and 2 years later (follow-up). A MetS z-score was computed with waist circumference (WC), insulin resistance index, blood pressure, high-density lipoprotein cholesterol and triglycerides. Metabolically unhealthy (MU) status was assessed. Multi-level linear and logistic regressions were performed. Results: Among the MetS markers, WC was more consistently associated with hsCRP cross-sectional and prospectively. Baseline MetS score was significantly associated with greater risk of high hsCRP at follow-up and with prevalence and incidence of hsCRP. Those children who became MU overtime were significantly (P <.05) associated with future higher levels of hsCRP, independently of weight status at baseline. Conclusions: Transition over time to a MU state was associated with higher levels of hsCRP at follow-up, independent of weight status at baseline. Screening of metabolic factors and routine measurement of WC are needed to prevent inflammatory status and related chronic diseases in children.

Idioma: Inglés

DOI: 10.1111/ijpo.12817

Año: 2021

Publicado en: Pediatric obesity 16, 11 (2021), e12817 [9 pp.]
ISSN: 2047-6302

Factor impacto JCR: 3.91 (2021)

Categ. JCR: PEDIATRICS rank: 27 / 130 = 0.208 (2021) - Q1 - T1

Factor impacto CITESCORE: 6.6 - Nursing (Q1) - Medicine (Q1)

Factor impacto SCIMAGO: 1.2 - Health Policy (Q1) - Public Health, Environmental and Occupational Health (Q1) - Nutrition and Dietetics (Q1)

Financiación: info:eu-repo/grantAgreement/EUR/FP6/FOOD-016181

Tipo y forma: Artículo (Versión definitiva)

Área (Departamento): Área Enfermería (Dpto. Fisiatría y Enfermería)
Área (Departamento): Área Medic.Prevent.Salud Públ. (Dpto. Microb.Ped.Radio.Sal.Pú.)