000153208 001__ 153208
000153208 005__ 20251017144625.0
000153208 0247_ $$2doi$$a10.1039/d4nr04219k
000153208 0248_ $$2sideral$$a143686
000153208 037__ $$aART-2025-143686
000153208 041__ $$aeng
000153208 100__ $$0(orcid)0000-0002-6116-9331$$aTorres, T. E.$$uUniversidad de Zaragoza
000153208 245__ $$aVanadium incorporation in ferrite nanoparticles serves as an electron buffer and anisotropy tuner in catalytic and hyperthermia applications
000153208 260__ $$c2025
000153208 5060_ $$aAccess copy available to the general public$$fUnrestricted
000153208 5203_ $$aCancer research has gradually shifted its focus from individual therapies to a combination of them for enhanced treatment effectiveness. In particular, the increased interest in the field of catalytic medicine through nanozymes proposes promising combinations with photothermal therapy, photodynamic therapy, and magnetic fluid hyperthermia (MFH). Nanozyme activity centers around the hydroxyl radical ˙OH, the most toxic of the reactive oxygen species (ROS). With a synergistic approach in mind, we studied VxFe3−xO4 magnetic nanoparticles (MNPs) as agents for ROS production and heating. These MNPs were exhaustively characterised both morphologically and magnetically. A compositional analysis through electron microscopy and spectroscopy unveils a core–shell structure with a V-rich shell. A study of the power absorption of these MNPs fixed into a gel matrix, emulating cytosol viscosity, provides values of up to 1000 W g−1 for samples with 0.5 wt% MNPs, an AC magnetic field amplitude of 65 mT and a frequency of 350 kHz, typical in the MFH application. A concentration of the ˙OH-adduct of up to 2300 nM has been measured through electron spin resonance analysis as a result of peroxidase-like activity. Through the comparison with similarly-sized ferrite MNPs, we determined that V incorporation lowers the magnetic anisotropy and serves as an electron buffer, explaining the enhanced MFH and ROS-production results.
000153208 536__ $$9info:eu-repo/grantAgreement/ES/AEI/PID2023-151080NB-I00$$9info:eu-repo/grantAgreement/ES/DGA/E13-23R$$9info:eu-repo/grantAgreement/EC/H2020/101007629 /EU/Nanomaterials for Enzymatic Control of Oxidative Stress Toxicity and Free Radical Generation/NESTOR$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 101007629 -NESTOR$$9info:eu-repo/grantAgreement/EC/H2020/101007825/EU/ULtra ThIn MAgneto Thermal sEnsor-Ing/ULTIMATE-I$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 101007825-ULTIMATE-I$$9info:eu-repo/grantAgreement/ES/MICIU/CEX2023-001286-S$$9info:eu-repo/grantAgreement/ES/MICIU/PID2019-106947RB-C21$$9info:eu-repo/grantAgreement/ES/UZ/UZ2023-CIE-02
000153208 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttps://creativecommons.org/licenses/by/4.0/deed.es
000153208 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000153208 700__ $$aValdés, D. P.
000153208 700__ $$0(orcid)0000-0002-9102-7895$$aHettler, S.
000153208 700__ $$aNuñez, J. M.
000153208 700__ $$aRodrigo, I.
000153208 700__ $$aOrue, I.
000153208 700__ $$aGarcía, J. Á.
000153208 700__ $$aPlazaola, F.
000153208 700__ $$aZysler, R. D.
000153208 700__ $$aLima, E.
000153208 700__ $$0(orcid)0000-0002-1296-4793$$aAguirre, M. H.$$uUniversidad de Zaragoza
000153208 700__ $$0(orcid)0000-0003-1558-9279$$aGoya, G. F.$$uUniversidad de Zaragoza
000153208 700__ $$aArenal, R.
000153208 7102_ $$12003$$2395$$aUniversidad de Zaragoza$$bDpto. Física Materia Condensa.$$cÁrea Física Materia Condensada
000153208 773__ $$g17, 16 (2025), 10205-10218$$pNanoscale$$tNanoscale$$x2040-3364
000153208 8564_ $$s2578940$$uhttps://zaguan.unizar.es/record/153208/files/texto_completo.pdf$$yVersión publicada
000153208 8564_ $$s2594999$$uhttps://zaguan.unizar.es/record/153208/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000153208 909CO $$ooai:zaguan.unizar.es:153208$$particulos$$pdriver
000153208 951__ $$a2025-10-17-14:23:56
000153208 980__ $$aARTICLE