000160955 001__ 160955
000160955 005__ 20251017144652.0
000160955 0247_ $$2doi$$a10.1039/d5na00123d
000160955 0248_ $$2sideral$$a144096
000160955 037__ $$aART-2025-144096
000160955 041__ $$aeng
000160955 100__ $$adel-Campo, Irene
000160955 245__ $$aAn organometallic approach to sub-2 nm thiolate-protected Au nanoclusters with enhanced catalytic and therapeutic properties
000160955 260__ $$c2025
000160955 5060_ $$aAccess copy available to the general public$$fUnrestricted
000160955 5203_ $$aThiolate-protected gold nanoclusters (AuNCs) of sub-2 nm size have been synthesized through a novel bottom-up approach using the organometallic precursor [Au(C6F5)(tht)] (tht = tetrahydrothiophene) in a one-pot reaction under mild conditions. This protocol is simple, rapid (1 h), versatile (applicable to thiolate ligands of varying molecular sizes), and reproducible, yielding AuNCs with low size dispersion. Furthermore, the resulting nanomaterials exhibited remarkable catalytic activity, effectively reducing the pollutant 4-nitrophenol to 4-aminophenol, as well as promising photothermal and photodynamic properties upon exposure to an 808 nm laser, converting light into thermal energy and generating reactive oxygen species (ROS). Additionally, AuNCs stabilized with a nonapeptide demonstrated efficient catalase-like activity, thereby potentially enhancing the efficacy of photodynamic therapy. The cytotoxic effects against cancer (HeLa) and healthy cells (HDF) were also evaluated, showing greater selectivity for HeLa cells, with higher toxicity and increased ROS generation.
000160955 536__ $$9info:eu-repo/grantAgreement/ES/AEI/PID2022-139739NB-I00$$9info:eu-repo/grantAgreement/EC/H2020/101034288/EU/International Fellowship Programme for Talent Attraction to the Campus of International Excellence Campus Iberus/IberusExperience$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 101034288-IberusExperience$$9info:eu-repo/grantAgreement/ES/MICINN/PID2021-127622OB-I00
000160955 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc$$uhttps://creativecommons.org/licenses/by-nc/4.0/deed.es
000160955 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000160955 700__ $$aSorroche, Alba
000160955 700__ $$aAllen, Nina
000160955 700__ $$0(orcid)0000-0002-2855-4801$$aGhirardello, Mattia$$uUniversidad de Zaragoza
000160955 700__ $$aCorzana, Francisco
000160955 700__ $$aGalán, M. Carmen
000160955 700__ $$aMonge, Miguel
000160955 700__ $$aLópez-de-Luzuriaga, José M.
000160955 7102_ $$12013$$2765$$aUniversidad de Zaragoza$$bDpto. Química Orgánica$$cÁrea Química Orgánica
000160955 773__ $$g(2025), [8 pp.]$$tNanoscale Advances$$x2516-0230
000160955 8564_ $$s1071676$$uhttps://zaguan.unizar.es/record/160955/files/texto_completo.pdf$$yVersión publicada
000160955 8564_ $$s2887759$$uhttps://zaguan.unizar.es/record/160955/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000160955 909CO $$ooai:zaguan.unizar.es:160955$$particulos$$pdriver
000160955 951__ $$a2025-10-17-14:36:56
000160955 980__ $$aARTICLE