000161094 001__ 161094
000161094 005__ 20251017144632.0
000161094 0247_ $$2doi$$a10.1113/JP288197
000161094 0248_ $$2sideral$$a144292
000161094 037__ $$aART-2025-144292
000161094 041__ $$aeng
000161094 100__ $$aBueno-Palomeque, Freddy L.
000161094 245__ $$aElectrophysiological characterization of pre‐adolescents born with intrauterine growth restriction: insights from clinical and computational data
000161094 260__ $$c2025
000161094 5060_ $$aAccess copy available to the general public$$fUnrestricted
000161094 5203_ $$aAnatomical changes associated with intra-uterine growth restriction (IUGR) have been observed in different age groups and linked to cardiovascular complications. This study analysed the electrocardiogram (ECG) in pre-adolescents with severe IUGR, comparing QRS complex and T-wave biomarkers with controls. Computer simulations explored links between anatomical re-modelling and ECG biomarkers, providing insights into the potential cardiovascular risk associated with IUGR-induced re-modelling. Clinical recordings were analysed using principal component analysis (PCA) to compute spatially transformed leads, enhancing QRS complex and T-wave delineation for depolarization and repolarization assessment. Transformed leads analysis revealed a 4-ms increase in QRS complex duration (QRS ) and a 2-ms increase in the T peak-to-end interval (T ) in IUGR subjects compared to controls. We conducted electrophysiological in silico simulations using anatomical models based on clinical IUGR data. These models, derived from a reference control, incorporated key geometric changes associated with IUGR, the apex-base length, basal diameter, wall thickness () and ventricular tissue volume, to assess their impact on depolarization and repolarization intervals. In silico PCA leads showed increased QRS , QRS amplitude and T in globular models, consistent with clinical data. Despite the QRS increase, the QT interval increases but is not linearly related to the change. These findings suggest that cardiac re-modelling primarily influences the depolarization cycle, notably QRS , while repolarization intervals increase but are not directly related to the increase. The study highlights the impact of geometric and volumetric changes in IUGR-related cardiac re-modelling, also emphasizing the need for further research on electrophysiological re-modelling and its effects on cardiac function.
000161094 536__ $$9info:eu-repo/grantAgreement/ES/AEI/PID2021-128972OA-I00$$9info:eu-repo/grantAgreement/ES/DGA/T39-23R$$9info:eu-repo/grantAgreement/ES/MICINN/CNS2022-135899$$9info:eu-repo/grantAgreement/ES/MICINN/PID2022-140556OB-I00$$9info:eu-repo/grantAgreement/ES/MICINN/RYC2019-027420-I$$9info:eu-repo/grantAgreement/EUR/MICINN/TED2021-130459B-I00
000161094 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc$$uhttps://creativecommons.org/licenses/by-nc/4.0/deed.es
000161094 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000161094 700__ $$aZacur, Ernesto
000161094 700__ $$0(orcid)0000-0002-1960-407X$$aPueyo, Esther$$uUniversidad de Zaragoza
000161094 700__ $$aCrispi, Fàtima
000161094 700__ $$0(orcid)0000-0003-3434-9254$$aLaguna, Pablo$$uUniversidad de Zaragoza
000161094 700__ $$0(orcid)0000-0003-3183-4107$$aMincholé, Ana$$uUniversidad de Zaragoza
000161094 7102_ $$15008$$2800$$aUniversidad de Zaragoza$$bDpto. Ingeniería Electrón.Com.$$cÁrea Teoría Señal y Comunicac.
000161094 773__ $$g(2025), [20 pp.]$$pJ. physiol.$$tJOURNAL OF PHYSIOLOGY-LONDON$$x0022-3751
000161094 8564_ $$s2684106$$uhttps://zaguan.unizar.es/record/161094/files/texto_completo.pdf$$yVersión publicada
000161094 8564_ $$s2284345$$uhttps://zaguan.unizar.es/record/161094/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000161094 909CO $$ooai:zaguan.unizar.es:161094$$particulos$$pdriver
000161094 951__ $$a2025-10-17-14:26:56
000161094 980__ $$aARTICLE