NIR-II Photoresponsive Magnetoliposomes for Remote-Controlled Release and Magnetic Resonance Imaging

Fernández-Méndez, Laura ; Fernández-Afonso, Yilian ; Martínez-Vicente, Pablo (Universidad de Zaragoza) ; Urkola-Arsuaga, Ainhize ; Miranda-Pérez de Alejo, Claudia ; L. de la Pisa, Irati ; Plaza-García, Sandra ; Ruíz-Cabello, Jesús ; Ramos-Cabrer, Pedro ; Gutiérrez, Lucía ; Carregal-Romero, Susana

Resumen: Magnetic nanoparticles, especially iron oxide nano-particles, have become versatile and widely used tools in nanomedicinedue to their unique magnetic properties, biocompatibility, and tunablefunctionality. Liposomes have further enhanced the potential of ironoxide nanoparticles by serving as effective nanocarriers with advantagessuch as drug coencapsulation and enhanced molecular imagingproperties. In this study, we present magnetoliposomes composed ofultrasmall free-floating iron oxide nanoparticles inside liposomes (LP-IONPs) and thermoresponsive phospholipids, which were designed asdual T2-T1 magnetic resonance imaging (MRI) contrast agents forimage-guided liposome degradation and infrared light-responsivenanocarriers in the second biological window for remote-controlleddrug delivery. We demonstrated a dynamic shift from T2 to T1 MRIcontrast during intracellular degradation of LP-IONPs, along with successful light-activated drug release in cancer cells.Biodistribution studies using MRI and histological analysis confirmed their potential for in vivo applications. These results highlightthe potential of LP-IONPs as image-guided and remote-controlled drug delivery systems.

Idioma: Inglés

DOI: 10.1021/acsabm.5c00233

Año: 2025

Publicado en: ACS Applied Bio Materials (2025), [15 pp.]
ISSN: 2576-6422

Financiación: info:eu-repo/grantAgreement/ES/AEI/AEI PID2021-123238OB-I00
Financiación: info:eu-repo/grantAgreement/ES/DGA/E15-23R
Financiación: info:eu-repo/grantAgreement/ES/MCIN/PID2019-106139RA-100
Financiación: info:eu-repo/grantAgreement/ES/MICINN/CNS2023-143944
Financiación: info:eu-repo/grantAgreement/ES/MICINN/CNS2023-144321
Financiación: info:eu-repo/grantAgreement/ES/MICINN/RYC2020-030241-I

Tipo y forma: Article (PostPrint)

Área (Departamento): Area Anatom.Embriol.Humana (Dpto. Anatom.Histolog.Humanas)