Recent advances in versatile cellulose-based 3D-printed drug delivery systems: A review

Wang, Kanglei ; Wu, Yanbei ; Remón, Javier (Universidad de Zaragoza) ; Ding, Wei

Resumen: Advancing effective drug therapies is crucial for improving human health. However, traditional drug delivery systems (DDSs) struggle to customize formulations for individual patient needs, prompting exploring innovative solutions. The emergence of 3D printing (3DP) technology allows for designing customized DDSs. Cellulose and its derivatives can positively lower blood cholesterol and stabilize blood glucose levels due to their excellent biocompatibility and safety. These cellulose-based materials are supposed to fulfill the necessary criteria for biocompatibility, printability, and biomanufacturing in DDSs. Despite their excellent potential and promising features, constructing 3D-printed DDSs utilizing nanocellulose (NC) and cellulose derivatives remains largely unexamined. Given this, our review highlights the recent advances in cellulose-based inks for drug delivery, detailing the multifunctional roles of cellulose derivatives, such as adhesives, drug-loaded filaments, controlled-release materials, thickeners, and fillers. Their versatility impacts ink rheology, allowing for tailored mechanical properties and porous structures in DDSs, including tablets, capsules, dispersible films, or scaffolds. Furthermore, their in vitro and in vivo application performances have been rigorously evaluated. Overall, this review emphasizes for the first time the unique advantages and various applications of 3D-printed cellulose-based DDSs in personalized medicine, which is significant in providing guidance for developing safe biomedical materials, triggering the growth of personalized medicine.

Idioma: Inglés

DOI: 10.1016/j.ijbiomac.2025.144433

Año: 2025

Publicado en: International journal of biological macromolecules 314 (2025), 144433 [20 pp.]
ISSN: 0141-8130

Financiación: info:eu-repo/grantAgreement/ES/AEI/RYC2021-033368-I
Financiación: info:eu-repo/grantAgreement/ES/DGA/T22-23R

Tipo y forma: Article (PostPrint)

Área (Departamento): Área Ingeniería Química (Dpto. Ing.Quím.Tecnol.Med.Amb.)