Evolving Platinum‐Copper Nanostructures for Enhanced Photothermal Therapy and Controlled Copper Release in Cancer Therapy
Garcia-Peiro, Jose I. (Universidad de Zaragoza) ; Sancho-Albero, María (Universidad de Zaragoza) ; Miguel, Silvia ; Mosseri, Andrea ; Hornos, Felipe ; Contreras-Montoya, Rafael ; Hueso, Jose L. (Universidad de Zaragoza) ; Santamaria, Jesus (Universidad de Zaragoza)
Resumen: Nanotechnology provides a panoply of new tools in cancer therapy, enabling advanced treatments such as chemodyamic therapy (CDT), radiation therapy (RT), photothermal therapy (PTT) or photodynamic therapy (PDT). The therapeutic effect can be increased by combining one or more of these actions and this is usually considered already from the design of the nanoparticles (NPs). Bimetallic NPs are obvious candidates in this respect, being able to trigger a multifunctional response associated to each metal and achieving a synergistic action in combined therapies. In this work, we designed platinum‐copper bimetallic NPs (PtCu NPs) capable to evolve during treatment and fulfill a dual role as chemotherapeutic agents, (controlled release of ionic Cu), and as tumor ablation agents under near infrared (NIR) irradiation. Tuning the synthesis conditions demonstrated the influence of metal composition and alloying degree on the Cu release pattern when exposed to physiological media. The Cu ions released disrupt the redox balance in cells by generating reactive hydrogen species (likely hydroxyl radicals •OH through reaction with H2O2 overexpressed in the tumor microenvironment) while simultaneously oxidizing glutathione (GSH). After Cu release, the remaining Pt‐rich structures present enhanced photothermal (PT) response. The efficacy of the combined therapy enabled by these NPs has been evaluated in vitro and in vivo.
Idioma: Inglés
DOI: 10.1002/adfm.202502999
Año: 2025
Publicado en: Advanced Functional Materials (2025), e02999 [15 PP.]
ISSN: 1616-301X
Tipo y forma: Article (Published version)
Área (Departamento): Área Ingeniería Química (Dpto. Ing.Quím.Tecnol.Med.Amb.)
Área (Departamento): Área Tecnologi. Medio Ambiente (Dpto. Ing.Quím.Tecnol.Med.Amb.)
You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. You may not use the material for commercial purposes.
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Idioma: Inglés
DOI: 10.1002/adfm.202502999
Año: 2025
Publicado en: Advanced Functional Materials (2025), e02999 [15 PP.]
ISSN: 1616-301X
Tipo y forma: Article (Published version)
Área (Departamento): Área Ingeniería Química (Dpto. Ing.Quím.Tecnol.Med.Amb.)
Área (Departamento): Área Tecnologi. Medio Ambiente (Dpto. Ing.Quím.Tecnol.Med.Amb.)
You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. You may not use the material for commercial purposes. Exportado de SIDERAL (2025-10-17-14:18:05)
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Articles > Artículos por área > Tecnologías del Medio Ambiente
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Record created 2025-07-22, last modified 2025-10-17