Clinical parameters predicted the progression to dementia in oldest old patients with mild cognitive impairment (MCI)

Molina-Torres, Nora (Universidad de Zaragoza) ; Platero, Carlos ; Pérez-Berasategui, Oscar (Universidad de Zaragoza) ; Andrés-Benito, Pol ; Povedano, Mónica ; Mesa-Lampré, Pilar ; Abadía-Morales, María ; Calvo, Ana-Cristina (Universidad de Zaragoza) ; Lobo, Antonio (Universidad de Zaragoza) ; De La Cámara-Izquierdo, Concepción (Universidad de Zaragoza) ; Osta, Rosario (Universidad de Zaragoza)

Resumen: Background: This study intends to assess to what extent instruments commonly used in clinical practice, as well as plasma p-tau-181, can predict the progression from MCI to dementia. The usefulness of a disease progression model (DPM) is also explored.
Methods: A longitudinal, prospective nested case-control study was conducted with patients from the Geriatrics outpatient clinics who met the MCI International Working Group criteria. The patients had a first clinical interview and two follow-ups after 12 and 24 months. Validated Spanish instruments were used for assessment, including the Mini-Mental State Examination (MMSE), the clock test, verbal fluency, the EURO-D depression scale, Barthel’s Index, and Lawton’s Index. P-tau-181 analysis was performed with SIMOA (Single MOlecule Array). A robust parametric disease progression model (RPDPM) was developed.
Results. Fifty-nine patients fulfilled the inclusion criteria. The median age was 82.7 + /−8.7 years, 93 % had amnestic MCI and 45.8 % progressed to dementia (ICD-11 criteria) in two years. P-tau-181 was not prognostic. An RPDPM with the MMSE, clock test, and Lawton’s Index could predict progression to dementia with an AUC of 0.945.
Conclusion: A combination of the MMSE, clock test, and Lawton’s Index in a DPM model predicted progression from MCI to dementia best. P-tau and other blood biomarkers did not predict progression. Our results highlight the strength of clinical variables to predict the progression of MCI.

Idioma: Inglés

DOI: 10.1016/j.inpsyc.2025.100129

Año: 2025

Publicado en: International Psychogeriatrics (2025), 100129 [8 pp.]
ISSN: 1041-6102

Financiación: info:eu-repo/grantAgreement/ES/DGA/A19-23R
Financiación: info:eu-repo/grantAgreement/ES/FIS/PI21-00286
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/FEDER/PI21-00372

Tipo y forma: Article (Published version)

Área (Departamento): Área Enfermería (Dpto. Fisiatría y Enfermería)
Área (Departamento): Área Genética (Dpto. Anatom.,Embri.Genét.Ani.)
Área (Departamento): Area Medicina (Dpto. Medicina, Psiqu. y Derm.)
Área (Departamento): Area Psiquiatría (Dpto. Medicina, Psiqu. y Derm.)