Five-repetition chair-stand test vs. handgrip strength: Which better predicts mortality risk? a follow-up study in 43,605 middle-aged and older adults

Núñez-Cortés, Rodrigo ; Andersen, Lars Louis ; Cruz-Montecinos, Carlos ; Polo-López, Ana ; López-Bueno, Rubén ; Calatayud, Joaquín

Resumen: Background: Ageing reduces muscle strength and function, increasing mortality risk. Identifying simple performance markers can guide interventions for healthy ageing.

Objective: To assess the prospective dose-response association of the 5-repetition Chair Stand Test (5-CST) and handgrip strength (HGS) with mortality in middle-aged and older adults. Methods: This prospective study included community-dwelling participants aged 50 years or older from the SHARE study. HGS and 5-CST were assessed at baseline, with all-cause mortality tracked through follow-up interviews. Cox regression with restricted cubic splines was used, controlling for several confounders.

Results: 43,605 participants (mean age (SD): 65.3 (9.1), 54 % women) were included. During a mean follow-up of 7.3 ± 2.2 years, there were 4154 deaths (9.5 %). Both 5-CST and HGS were curvilinearly associated with all- cause mortality. Using the median level of 5-CST as a reference (11 s), 10th percentile of 5-CST (7 s) showed a hazard ratio (HR) of 0.74 (95 %CI: 0.69, 0.80). The 90th percentile (18 s) of 5-CST showed a HR of 1.18 (95 % CI: 1.14, 1.22). Stratified analysis indicated 5-CST was most strongly associated with mortality in women. Regarding HGS, using the median level as a reference (33 kg), the 10th percentile of muscle strength (21 kg) showed a HR of 1.62 (95 %CI: 1.50, 1.75). The 90th percentile (51 kg) of muscle strength showed a HR of 0.58 (95 %CI: 0.52, 0.64).

Conclusion: Both tools provide valuable information, but HGS may be considered more relevant for identifying those at increased mortality risk, while 5-CST may be especially useful in women.

Idioma: Inglés

DOI: 10.1016/j.bjpt.2025.101529

Año: 2025

Publicado en: Revista Brasileira de Fisioterapia 29, 6 (2025), 101529 [7 p.]
ISSN: 1413-3555

Tipo y forma: Artículo (Versión definitiva)