000163271 001__ 163271
000163271 005__ 20251030145434.0
000163271 0247_ $$2doi$$a10.1093/eurheartj/ehaf530
000163271 0248_ $$2sideral$$a145738
000163271 037__ $$aART-2025-145738
000163271 041__ $$aeng
000163271 100__ $$aMunroe, Patricia B
000163271 245__ $$aIdentification of plasma protein mediators of blood pressure and cardiovascular disease: what are the next steps?
000163271 260__ $$c2025
000163271 5060_ $$aAccess copy available to the general public$$fUnrestricted
000163271 5203_ $$aBackground: There are strong epidemiological data demonstrating an association between blood pressure (BP) and increased risk of cardiovascular events including coronary artery disease (CAD) and stroke. Over recent years, genome-wide association studies (GWAS) have been performed separately for each trait, with many discovered loci, and BP polygenic risk scores have demonstrated significant associations with both cardiovascular outcomes. Pleiotropic genetic variants (the same variant associated with more than one phenotype) have also been reported across BP, CAD, and stroke. With the advent of high-throughput protein profiling assays, researchers are now linking genetic associations to protein expression as a next step in the discovery of effector proteins and disease mechanisms. The study by Meena et al. published in this issue of the European Heart Journal explores whether there is a set of shared plasma proteins between BP, CAD, and stroke that influence cardiovascular risk by their effects on BP using a Mendelian randomization (MR) framework and co- localization analyses...
000163271 540__ $$9info:eu-repo/semantics/embargoedAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000163271 655_4 $$ainfo:eu-repo/semantics/other$$vinfo:eu-repo/semantics/acceptedVersion
000163271 700__ $$aYoung, William J
000163271 700__ $$0(orcid)0000-0003-4130-5866$$aRamírez, Julia$$uUniversidad de Zaragoza
000163271 7102_ $$15008$$2800$$aUniversidad de Zaragoza$$bDpto. Ingeniería Electrón.Com.$$cÁrea Teoría Señal y Comunicac.
000163271 773__ $$g(2025), [3 pp.]$$pEur. heart j.$$tEuropean heart journal$$x0195-668X
000163271 8564_ $$s935469$$uhttps://zaguan.unizar.es/record/163271/files/texto_completo.pdf$$yPostprint$$zinfo:eu-repo/date/embargoEnd/2026-10-10
000163271 8564_ $$s1113340$$uhttps://zaguan.unizar.es/record/163271/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint$$zinfo:eu-repo/date/embargoEnd/2026-10-10
000163271 909CO $$ooai:zaguan.unizar.es:163271$$particulos$$pdriver
000163271 951__ $$a2025-10-30-14:52:11
000163271 980__ $$aARTICLE