000163868 001__ 163868 000163868 005__ 20251107115329.0 000163868 0247_ $$2doi$$a10.1186/s40479-025-00316-0 000163868 0248_ $$2sideral$$a145977 000163868 037__ $$aART-2025-145977 000163868 041__ $$aeng 000163868 100__ $$aLaffite, Horus 000163868 245__ $$aLatent class analysis of women with borderline personality disorder: the role of adverse childhood experiences in impulsivity, emotional dysregulation, and neurocognitive profiles 000163868 260__ $$c2025 000163868 5060_ $$aAccess copy available to the general public$$fUnrestricted 000163868 5203_ $$aIntroduction: Borderline personality disorder (BPD) is a complex psychiatric condition strongly associated with adverse childhood experiences (ACEs). This study examined how childhood trauma interacts with impulsivity, emotion dysregulation, and cognitive functioning to identify distinct clinical subtypes in women with BPD and inform personalized treatment strategies. Materials and methods: In this cross-sectional study, 231 women with BPD completed standardized assessments of childhood trauma (CTQ-SF), impulsivity (Barratt Impulsiveness Scale), and emotion regulation (DERS-SF), along with a neuropsychological battery. An exploratory latent class analysis identified subgroups based on trauma exposure and clinical features. Between-class differences in impulsivity, emotion regulation, and cognitive functioning were examined using ANOVA. Results: Five distinct clinical profiles emerged. The most severe classes—characterized by continuous sexual abuse (17.3%) and early sexual abuse with polysubstance use (25.1%)—showed the highest impulsivity, severe emotion regulation difficulties, and deficits in attention, working memory, and cognitive flexibility. A low-severity class with early sexual abuse (13.4%) exhibited moderate emotion regulation challenges without cognitive impairments. In contrast, two classes without sexual abuse—minimal trauma or violence (31.6%) and violence with substance use (12.6%)—demonstrated better emotional and cognitive functioning, with the low-trauma group displaying the lowest impulsivity and symptom severity. Conclusions: These findings underscore the importance of trauma-informed and cognitively tailored interventions for enhancing therapeutic outcomes in women with BPD. Recognizing the interplay among trauma, impulsivity, emotion dysregulation, and neurocognition may support more effective treatment planning and resource allocation. 000163868 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.es 000163868 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion 000163868 700__ $$aDíaz-Garrido, J. A. 000163868 700__ $$0(orcid)0000-0002-2259-2639$$aOrdóñez-Carrasco, J. L.$$uUniversidad de Zaragoza 000163868 700__ $$aHernández-Fleta, J. L. 000163868 700__ $$0(orcid)0000-0002-0403-5273$$aMartínez-Loredo, V. 000163868 7102_ $$14009$$2620$$aUniversidad de Zaragoza$$bDpto. Psicología y Sociología$$cÁrea Metod.Ciencias Comportam. 000163868 773__ $$g12, 1 (2025), [13 pp.]$$tBorderline Personality Disorder and Emotion Dysregulation$$x2051-6673 000163868 8564_ $$s1332997$$uhttps://zaguan.unizar.es/record/163868/files/texto_completo.pdf$$yVersión publicada 000163868 8564_ $$s2080009$$uhttps://zaguan.unizar.es/record/163868/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000163868 909CO $$ooai:zaguan.unizar.es:163868$$particulos$$pdriver 000163868 951__ $$a2025-11-07-10:26:19 000163868 980__ $$aARTICLE