000163899 001__ 163899
000163899 005__ 20251113160752.0
000163899 0247_ $$2doi$$a10.1080/19440049.2017.1346390
000163899 0248_ $$2sideral$$a101591
000163899 037__ $$aART-2017-101591
000163899 041__ $$aeng
000163899 100__ $$0(orcid)0000-0002-9804-8699$$aÚbeda, S.$$uUniversidad de Zaragoza
000163899 245__ $$aOverall and specific migration from multilayer high barrier food contact materials–kinetic study of cyclic polyester oligomers migration
000163899 260__ $$c2017
000163899 5060_ $$aAccess copy available to the general public$$fUnrestricted
000163899 5203_ $$aMost multilayer high barrier materials used in food packaging have a polyurethane adhesive layer in their structures. In order to assess the safety of these materials, it is important to determine the compounds intentionally added to the adhesives (IAS) as well as those non-intentionally added substances (NIAS). During the manufacture of polyurethane adhesives, some by-products can be formed, such as cyclic polyester oligomers coming from the reaction between dicarboxylic acids and glycols. Since these compounds are not listed in the Regulation 10/2011/EU, they should not be found in migration above 0.01 mg/kg of simulant. In this study two flexible multilayer packaging materials were used and migration was evaluated in simulant A (ethanol 10% v/v), simulant B (acetic acid 3% w/v) and simulant ethanol 95% v/v during 10 days at 60ºC. Identification and quantification of non-volatile compounds was carried out by UPLC-MS-QTOF. Most of migrants were oligomers such as cyclic polyesters and caprolactam oligomers. Overall migration and specific migration of adipic acid-diethylene glycol and phthalic acid-diethylene glycol were monitored over time and analysed by UPLC-MS-TQ. In most cases, ethanol 95% v/v was the simulant with the highest concentration values. Overall migration kinetics followed a similar pattern than specific migration kinetics.
000163899 536__ $$9info:eu-repo/grantAgreement/ES/MINECO/AGL2012-37886$$9info:eu-repo/grantAgreement/ES/MINECO/AGL2015-67362-P$$9info:eu-repo/grantAgreement/ES/MINECO/RYC-2012-11856
000163899 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
000163899 590__ $$a2.129$$b2017
000163899 591__ $$aCHEMISTRY, APPLIED$$b30 / 70 = 0.429$$c2017$$dQ2$$eT2
000163899 591__ $$aFOOD SCIENCE & TECHNOLOGY$$b50 / 133 = 0.376$$c2017$$dQ2$$eT2
000163899 591__ $$aTOXICOLOGY$$b57 / 93 = 0.613$$c2017$$dQ3$$eT2
000163899 592__ $$a0.74$$b2017
000163899 593__ $$aFood Science$$c2017$$dQ1
000163899 593__ $$aToxicology$$c2017$$dQ2
000163899 593__ $$aMedicine (miscellaneous)$$c2017$$dQ2
000163899 593__ $$aPublic Health, Environmental and Occupational Health$$c2017$$dQ2
000163899 593__ $$aChemistry (miscellaneous)$$c2017$$dQ2
000163899 593__ $$aHealth, Toxicology and Mutagenesis$$c2017$$dQ2
000163899 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000163899 700__ $$0(orcid)0000-0002-0759-9170$$aAznar, M.$$uUniversidad de Zaragoza
000163899 700__ $$0(orcid)0000-0002-8765-4319$$aVera, P.$$uUniversidad de Zaragoza
000163899 700__ $$0(orcid)0000-0003-2685-5739$$aNerín, C.$$uUniversidad de Zaragoza
000163899 700__ $$aHenríquez, L.
000163899 700__ $$aTaborda, L.
000163899 700__ $$aRestrepo, C.
000163899 7102_ $$12009$$2750$$aUniversidad de Zaragoza$$bDpto. Química Analítica$$cÁrea Química Analítica
000163899 7102_ $$12009$$2X$$aUniversidad de Zaragoza$$bDpto. Química Analítica$$cProy. investigación HVA
000163899 773__ $$g34, 10 (2017), 1784-1794$$pFood Addit. Contam., Part A, Analysis control expo. risk assess.$$tFood Additives and Contaminants - Part A Chemistry, Analysis, Control, Exposure and Risk Assessment$$x1944-0049
000163899 8564_ $$s522121$$uhttps://zaguan.unizar.es/record/163899/files/texto_completo.pdf$$yPostprint
000163899 8564_ $$s2662814$$uhttps://zaguan.unizar.es/record/163899/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000163899 909CO $$ooai:zaguan.unizar.es:163899$$particulos$$pdriver
000163899 951__ $$a2025-11-13-14:57:26
000163899 980__ $$aARTICLE