Direct Hydroxymethylation of C=N Double Bonds

Merino, P. (Universidad de Zaragoza) ; Tejero, T. (Universidad de Zaragoza) ; Delso, I. (Universidad de Zaragoza) ; Juste, V. (Universidad de Zaragoza) ; Pedron, M. (Universidad de Zaragoza) ; Orta, S. (Universidad de Zaragoza) ; Matute, R. (Universidad de Zaragoza)

Resumen: Direct hydroxymethylation of C=N double bonds including imines, nitrones, oximes, hydrazones and iminium salts is a less explored synthetic approach to 1, 2-amino alcohols that provides good alternatives to the classical methods. The review deals with nucleophilic additions of organometallic hydroxymethyl reagents and lithiated alkoxyallenes to C=N double bonds. Reductive cross couplings between C=N double bonds and aldehydes or ketones are also discussed.

Idioma: Inglés

DOI: 10.2174/1570178614666171121144234

Año: 2018

Publicado en: LETTERS IN ORGANIC CHEMISTRY 15, 5 (2018), 375-386
ISSN: 1570-1786

Factor impacto JCR: 0.723 (2018)

Categ. JCR: CHEMISTRY, ORGANIC rank: 52 / 57 = 0.912 (2018) - Q4 - T3

Factor impacto SCIMAGO: 0.205 - Organic Chemistry (Q4) - Biochemistry (Q4)

Financiación: info:eu-repo/grantAgreement/ES/DGA/E10
Financiación: info:eu-repo/grantAgreement/ES/MINECO-FEDER/CTQ2016-76155-R

Tipo y forma: Review (Published version)

Área (Departamento): Área Química Orgánica (Dpto. Química Orgánica)
Área (Departamento): Área Tecnologi. Medio Ambiente (Dpto. Ing.Quím.Tecnol.Med.Amb.)