Cyclometallated Iridium(III) Complexes: Ligand-Driven Selectivity for Chemotherapy and Photodynamic Therapy
Fernández-Moreira, Vanesa ; Morales-Pioz, Eva (Universidad de Zaragoza) ; Redrado, Marta ; Benedí Visiedo, Andrea ; Aquino, Araceli de ; García-Orduña, Pilar ; Royo-Cañas, María ; Godino, Javier ; Marzo, Isabel ; Rodriguez, Laura ; Gimeno, M. Concepción
Resumen: This study explores two cyclometallated Ir(III) complex families with distinct therapeutic profiles. Benzothiophene derivatives (1, 2) exhibit potent antiproliferative character in the dark, favoring chemotherapy, while benzothiazole analogs (3 and 4) show high photocytotoxicity, ideal for photodynamic therapy. Photophysical studies and subcellular localization analyses highlight ligand-driven selectivity and the role of organelle targeting in therapeutic outcomes.
Idioma: Inglés
DOI: 10.1039/D5CC04768D
Año: 2025
Publicado en: Chemical Communications
ISSN: 1359-7345
Tipo y forma: Article (PostPrint)
Área (Departamento): Área Química Inorgánica (Dpto. Química Inorgánica)
You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. You may not use the material for commercial purposes.
Exportado de SIDERAL (2025-11-13-14:58:00)
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Idioma: Inglés
DOI: 10.1039/D5CC04768D
Año: 2025
Publicado en: Chemical Communications
ISSN: 1359-7345
Tipo y forma: Article (PostPrint)
Área (Departamento): Área Química Inorgánica (Dpto. Química Inorgánica)
You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. You may not use the material for commercial purposes. Exportado de SIDERAL (2025-11-13-14:58:00)
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Record created 2025-11-13, last modified 2025-11-13