Successful Desensitization to Irinotecan After Severe Hypersensitivity Reaction

Cubero, J. L. ; Escudero, P. ; Yubero, A. ; Millan, P. (Universidad de Zaragoza) ; Sagredo, M. A. ; Colas, C. (Universidad de Zaragoza)

Resumen: Irinotecan is an antineoplastic drug that is widely used to treat gastrointestinal malignancies. It prevents DNA from unwinding by inhibition of topoisomerase I. Hypersensitivity reactions (HSRs), which can occur with most drugs, are unpredictable, can affect any organ or system, and range widely in clinical severity from mild pruritus to anaphylaxis. In most cases, the culprit drug is avoided in the future, but for certain patients, the particular drug may be essential for optimal therapy. Under these circumstances, desensitization to the drug in question is a viable option. This approach induces a temporary state of tolerance to the drug responsible for a proven HSR [2]. A 57-year-old man with a personal history of dyslipidemia, high blood pressure, and hyperuricemia and no history of allergy was diagnosed in June 2014 with a low rectal neoplasm 7 cm from the anal margin with synchronous liver metastases (T3N2M1). Short-course radiotherapy was administered, followed by laparoscopic ultralow anterior resection with manual colorectal anastomosis and removal of a surgical specimen through the anus (pass-through) with protective lateral ileostomy...

Idioma: Inglés

DOI: 10.18176/jiaci.0075

Año: 2016

Publicado en: Journal of Investigational Allergology and Clinical Immunology 26, 5 (2016), 314-316
ISSN: 1018-9068

Factor impacto JCR: 3.094 (2016)

Categ. JCR: IMMUNOLOGY rank: 74 / 149 = 0.497 (2016) - Q2 - T2
Categ. JCR: ALLERGY rank: 14 / 26 = 0.538 (2016) - Q3 - T2

Factor impacto SCIMAGO: 0.645 - Immunology and Allergy (Q3) - Immunology (Q3)

Tipo y forma: Congress (Published version)

Área (Departamento): Área Radiol. y Medicina Física (Dpto. Pediatría Radiol.Med.Fís)
Área (Departamento): Area Medicina (Dpto. Medicina, Psiqu. y Derm.)