Long-term impact of oral gestational PM10 exposure on morris water maze performance and hippocampal gene expression
Ruiz-Sobremazas, Diego (Universidad de Zaragoza) ; Coca, Mario ; Morales-Navas, Miguel ; Rios Nieto, Nerea ; Rodulfo-Cárdenas, Rocío ; Colomina, Maria Teresa ; López-Granero, Caridad (Universidad de Zaragoza) ; Sanchez-Santed, Fernando ; Pérez-Fernández, Cristian
Resumen: Environmental exposure to air pollution, specially to particulate matter (PM) during pregnancy, plays a significant role in increasing the risk of neurodevelopmental disorders such as autism. This study investigated the long-term impact of oral gestational PM exposure (200 µg/kg/day) on memory in aged rats using the Morris Water Maze (MWM). After completing MWM, hippocampal tissue was collected and analyzed for gene expression. Our findings indicate that gestational PM exposure caused no major developmental alterations, aside from slightly poorer performance in the adherence test. No differences were detected in standard MWM manipulations, however, PM-offspring showed reduced latency in the test session, suggesting a possible compulsive-like behavior. Additionally, hippocampal gene expression revealed downregulation of several genes, including NMDA and GABAergic subunits. These effects depended on exposure and sex. The behavioral effects might reflect cognitive inflexibility linked to gene alterations. Further research is needed to clarify these outcomes.
Idioma: Inglés
DOI: 10.1016/j.etap.2025.104874
Año: 2025
Publicado en: ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY 120 (2025), 104874 [16 pp.]
ISSN: 1382-6689
Financiación: info:eu-repo/grantAgreement/ES/MICINN/PID2020-113812RB-C31/AEI/10.13039/501100011033
Financiación: info:eu-repo/grantAgreement/ES/MICINN/PID2020-113812RB-C32/AEI/10.13039/501100011033
Financiación: info:eu-repo/grantAgreement/ES/MICINN/PID2020-113812RB-C33/AEI/10.13039/501100011033
Tipo y forma: Article (Published version)
Área (Departamento): Área Psicología Básica (Dpto. Psicología y Sociología)
You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. You may not use the material for commercial purposes.
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Idioma: Inglés
DOI: 10.1016/j.etap.2025.104874
Año: 2025
Publicado en: ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY 120 (2025), 104874 [16 pp.]
ISSN: 1382-6689
Financiación: info:eu-repo/grantAgreement/ES/MICINN/PID2020-113812RB-C31/AEI/10.13039/501100011033
Financiación: info:eu-repo/grantAgreement/ES/MICINN/PID2020-113812RB-C32/AEI/10.13039/501100011033
Financiación: info:eu-repo/grantAgreement/ES/MICINN/PID2020-113812RB-C33/AEI/10.13039/501100011033
Tipo y forma: Article (Published version)
Área (Departamento): Área Psicología Básica (Dpto. Psicología y Sociología)
You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. You may not use the material for commercial purposes. Exportado de SIDERAL (2025-12-19-14:42:16)
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Record created 2025-12-19, last modified 2025-12-19