Resumen: The aim of this study was to determine the prevalence and predictors of problematic smartphone use (PSU) in a sample of young Spanish university students. A descriptive cross-sectional study was conducted in a sample of university students. An online questionnaire collected data on socio-demographic characteristics, health-related behaviours, loneliness, life satisfaction and smartphone use. PSU was assessed using the Smartphone Addiction Scale-Short Version. Logistic regression analysis was used to examine predictors of PSU. 545 students (52.5% female) participated in the study. PSU was present in 33.8% of participants. PSU was associated with duration of device use (OR = 1.39; 95%CI 1.22–1.58), smartphone use before sleep (OR = 3.31; 95%CI 1.32–8.30), preferred use for entertainment purposes (OR = 5.03; 95%CI 1.32–19.17), smoking (OR = 1.75; 95%CI 1.07–2.87), alcohol consumption (OR = 1.60; 95%CI 1.30–1.98) and loneliness (OR = 1.20; 95%CI 1.03–1.40). In contrast, high physical activity was a protective factor for PSU (OR = 0.55; 95%CI 0.31–0.98). Prevalence of PSU is high among Spanish university students. Loneliness, smartphone use habits and certain health-related behaviours are predictors of PSU. Our findings highlight the need to formulate policies and institutional guidelines that promoted a balanced use of technology. Idioma: Inglés DOI: 10.1038/s41598-025-28829-2 Año: 2025 Publicado en: Scientific reports (Nature Publishing Group) 15, 45457 (2025), 12 ISSN: 2045-2322 Financiación: info:eu-repo/grantAgreement/ES/DGA/B53-23R Tipo y forma: Artículo (Versión definitiva) Área (Departamento): Área Enfermería (Dpto. Fisiatría y Enfermería)