Organocatalysed C-2 and C-3 functionalisation of chromones
Morales-Solís, Juan Carlos (Universidad de Zaragoza) ; Ordoñez, Mario ; Marqués-López, Eugenia ; Herrera, Raquel P.
Resumen: This review highlights the recent advancements in organocatalysed Michael addition reactions involving chromones, an important class of heterocyclic compounds with significant biological and pharmacological properties. Chromones, with their versatile conjugated structure, act as both electrophilic and nucleophilic partners, providing an ideal platform to synthesise diverse stereochemically enriched molecular frameworks. The work highlights various organocatalysed examples using chiral carbenes, phosphoric acids, thioureas and squaramides, that have demonstrated high efficiency and stereocontrol in a range of reactions. Mechanistic insights into how these catalytic systems activate the chromone scaffold and promote enantioselective transformations are also discussed in detail. Finally, we underline emerging trends and future directions in this research area, addressing current limitations, such as the need for more efficient catalytic systems and broader substrate compatibility.
Idioma: Inglés
DOI: 10.1039/d5ob01129a
Año: 2025
Publicado en: Organic & Biomolecular Chemistry 23, 46 (2025), 10420-10436
ISSN: 1477-0520
Financiación: info:eu-repo/grantAgreement/ES/DGA/E07-23R
Financiación: info:eu-repo/grantAgreement/ES/MICIU/AEI/10.13039/501100011033
Tipo y forma: Review (PostPrint)
Área (Departamento): Área Química Orgánica (Dpto. Química Orgánica)
You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. You may not use the material for commercial purposes.
Exportado de SIDERAL (2026-01-12-11:11:22)
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Idioma: Inglés
DOI: 10.1039/d5ob01129a
Año: 2025
Publicado en: Organic & Biomolecular Chemistry 23, 46 (2025), 10420-10436
ISSN: 1477-0520
Financiación: info:eu-repo/grantAgreement/ES/DGA/E07-23R
Financiación: info:eu-repo/grantAgreement/ES/MICIU/AEI/10.13039/501100011033
Tipo y forma: Review (PostPrint)
Área (Departamento): Área Química Orgánica (Dpto. Química Orgánica)
You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. You may not use the material for commercial purposes. Exportado de SIDERAL (2026-01-12-11:11:22)
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Record created 2026-01-12, last modified 2026-01-12