Polymorphism of genetic ambigrams

Dudas, Gytis ; Huber, Greg ; Wilkinson, Michael ; Yllanes, David

Resumen: Double synonyms in the genetic code can be used as a tool to test competing hypotheses regarding ambigrammatic narnavirus genomes. Applying the analysis to recent observations of Culex narnavirus 1 and Zhejiang mosquito virus 3 ambigrammatic viruses indicates that the open reading frame on the complementary strand of the segment coding for RNA-dependent RNA polymerase does not code for a functional protein. Culex narnavirus 1 has been shown to possess a second segment, also ambigrammatic, termed ‘Robin’. We find a comparable segment for Zhejiang mosquito virus 3, a moderately diverged relative of Culex narnavirus 1. Our analysis of Robin polymorphisms suggests that its reverse open reading frame also does not code for a functional protein. We make a hypothesis about its role.

Idioma: Inglés

DOI: 10.1093/ve/veab038

Año: 2021

Publicado en: Virus evolution 7, 1 (2021), veab038 [11 pp.]
ISSN: 2057-1577

Factor impacto JCR: 5.614 (2021)

Categ. JCR: VIROLOGY rank: 15 / 37 = 0.405 (2021) - Q2 - T2

Factor impacto CITESCORE: 6.1 - Immunology and Microbiology (Q2)

Factor impacto SCIMAGO: 2.256 - Virology (Q1) - Microbiology (Q1)

Tipo y forma: Article (Published version)