Evaluation of the toxicity profiles of three families of solvents from biomass: levulinate, lactate and furfural derivatives

Zuriaga, Estefanía ; Lomba, Laura ; García, Cristina B. ; Valero, Marta Sofia (Universidad de Zaragoza)

Resumen: Nowadays, the scientific community is looking for and developing new solvents, called green solvents, which, due to their physicochemical properties and their origin, can replace traditional solvents. Among the different types of these solvents are those derived from biomass, which seem to have properties suitable for Green Chemistry. In this study, a total of eleven solvents derived from biomass, divided into three families structurally related: levulinate, lactate and furfural, have been selected. For these solvents, the physicochemical and ecotoxicological properties have been previously studied; however, their toxicological profile is still poorly known. In this study, cytotoxicity is analyzed by exploring a wide range of biochemical pathways and changes in cell morphology, including different cell lines and an ex vivo model. Throughout the tests performed, it has been observed that most of the solvents in the furfural family have a higher toxicity profile than the rest of the solvents evaluated. In addition, many solvents, although not highly toxic, showed cellular morphological damage and stress responses that should be considered.

Idioma: Inglés

DOI: 10.1039/d3gc01669b

Año: 2023

Publicado en: GREEN CHEMISTRY 25, 18 (2023), 7344-7355
ISSN: 1463-9262

Factor impacto JCR: 9.3 (2023)

Categ. JCR: GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY rank: 14 / 91 = 0.154 (2023) - Q1 - T1
Categ. JCR: CHEMISTRY, MULTIDISCIPLINARY rank: 32 / 231 = 0.139 (2023) - Q1 - T1

Factor impacto CITESCORE: 16.1 - Environmental Chemistry (Q1) - Pollution (Q1)

Factor impacto SCIMAGO: 1.878 - Pollution (Q1) - Environmental Chemistry (Q1)

Financiación: info:eu-repo/grantAgreement/ES/DGA/B44-23R
Financiación: info:eu-repo/grantAgreement/ES/DGA/B58-23D
Financiación: info:eu-repo/grantAgreement/ES/UZ/JIUZ-2021-BIO-08

Tipo y forma: Article (Published version)

Área (Departamento): Área Fisiología (Dpto. Farmac.Fisiol.y Med.L.F.)