000168087 001__ 168087
000168087 005__ 20260126155509.0
000168087 0247_ $$2doi$$a10.1002/jsfa
000168087 0248_ $$2sideral$$a54811
000168087 037__ $$aART-2004-54811
000168087 041__ $$aeng
000168087 100__ $$0(orcid)0000-0002-2147-9263$$aRemon, S.$$uUniversidad de Zaragoza
000168087 245__ $$aAtmosphere Composition Effects on Burlat Cherry Colour During Cold Storage
000168087 260__ $$c2004
000168087 5060_ $$aAccess copy available to the general public$$fUnrestricted
000168087 5203_ $$aBACKGROUND
Phytochemicals have long been utilized as active ingredients in the developing of novel functional foods or drugs due to their diverse biological and pharmacological effects. Many studies have demonstrated that polyphenols exhibit low absorption rates and are extensively metabolized into various metabolites, resulting in significantly reduced bioavailability.
RESULTS
Puerarin and diosmin exhibited the highest transport from the apical (AP) to basolateral (BL) direction, while diosmin and silybin showed the highest BL to AP transport. Most polyphenols demonstrated well-absorbed characteristics based on their apparent permeability coefficients (Papp), except for flavokawain A, phloretin, chrysin and dicoumarol, which displayed incomplete bidirectional absorption. Hesperetin exhibited a notable efflux ratio (ER) of 5.45, suggesting increased efflux compared to other compounds. A strong positive correlation was observed for Papp in both directions (Pearson correlation coefficient (PCC) = 0.53, P < 0.001), with a moderate correlation between ER and Papp(BL→AP) (PCC = 0.49, P < 0.001). Principal component analysis highlighted Papp(BL→AP) as the most influential indicator for polyphenol permeability, explaining a relatively wide portion of the data variance. Polyphenol compounds with a higher number of functional groups, such as –OH and –CH3, exhibited enhanced absorption due to increased binding affinity with intestinal cells and interactions with intracellular proteins.
CONCLUSION
These findings offer valuable insights for expressing polyphenol permeability via Caco-2 cells and may contribute to strategies aimed at enhancing the biological activities of polyphenols. © 2025 The Author(s). Journal of the Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
000168087 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc$$uhttps://creativecommons.org/licenses/by-nc/4.0/deed.es
000168087 590__ $$a0.871$$b2004
000168087 591__ $$aAGRICULTURE, MULTIDISCIPLINARY$$b4 / 28 = 0.143$$c2004$$dQ1$$eT1
000168087 591__ $$aCHEMISTRY, APPLIED$$b26 / 56 = 0.464$$c2004$$dQ2$$eT2
000168087 591__ $$aFOOD SCIENCE & TECHNOLOGY$$b37 / 93 = 0.398$$c2004$$dQ2$$eT2
000168087 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000168087 700__ $$0(orcid)0000-0001-5765-2972$$aFerrer, A.$$uUniversidad de Zaragoza
000168087 700__ $$0(orcid)0000-0001-5992-2913$$aLopez Buesa, P.$$uUniversidad de Zaragoza
000168087 700__ $$0(orcid)0000-0001-8836-1983$$aOria, R.$$uUniversidad de Zaragoza
000168087 7102_ $$12008$$2780$$aUniversidad de Zaragoza$$bDpto. Produc.Animal Cienc.Ali.$$cÁrea Tecnología de Alimentos
000168087 773__ $$g84, 2 (2004), 140-146$$pJ. Sci. Food Agric.$$tJournal of the science of food and agriculture$$x0022-5142
000168087 8564_ $$s1360333$$uhttps://zaguan.unizar.es/record/168087/files/texto_completo.pdf$$yVersión publicada
000168087 8564_ $$s2651728$$uhttps://zaguan.unizar.es/record/168087/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000168087 909CO $$ooai:zaguan.unizar.es:168087$$particulos$$pdriver
000168087 951__ $$a2026-01-26-14:50:11
000168087 980__ $$aARTICLE