T wave alternans in experimental myocardial infarction: Time course and predictive value for the assessment of myocardial damage

Demidova, M. ; Martín-Yebra, A. ; Martínez, J.P. (Universidad de Zaragoza) ; Monasterio, V. (Universidad de Zaragoza) ; Koul, S. ; van der Pals, J ; Romero, D. ; Laguna, P. (Universidad de Zaragoza) ; Erlinge, D. ; Platonov, P.G.

Resumen: Background
T-wave alternans (TWA) is associated with prognosis after myocardial infarction (MI), however its link to the extent of ischemic injury has not been clarified. We analyzed the course of TWA and its relation to myocardial damage in experimental myocardial infarction.
Methods
In 21 pigs, infarction was induced by 40-minute long balloon inflation in LAD under continuous 12-lead ECG monitoring. TWA was assessed in a 32-beat sliding window, using periodic component analysis and the Laplacian Likelihood Ratio method. Myocardium at risk (MaR) and infarct size (IS) were evaluated by SPECT and magnetic resonance imaging respectively.
Results
TWA appeared at 7.2 ± 4.5 minutes of occlusion, reached its maximum at 12.7 ± 6.3 and lasted until 26.5 ± 9.2 minutes. The maximal level of TWA was associated with both MaR (r = 0.499, p = 0.035) and IS (r = 0.65, p = 0.004).
Conclusion
TWA magnitude is associated with both MaR and IS in experiment, which encourages further studies in clinical settings.

Idioma: Inglés

DOI: 10.1016/j.jelectrocard.2013.03.001

Año: 2013

Publicado en: JOURNAL OF ELECTROCARDIOLOGY 46, 3 (2013), 263-269
ISSN: 0022-0736

Factor impacto JCR: 1.363 (2013)

Categ. JCR: CARDIAC & CARDIOVASCULAR SYSTEMS rank: 84 / 125 = 0.672 (2013) - Q3 - T3

Tipo y forma: Article (PostPrint)

Área (Departamento): Área Ingen.Sistemas y Automát. (Dpto. Informát.Ingenie.Sistms.)
Área (Departamento): Área Teoría Señal y Comunicac. (Dpto. Ingeniería Electrón.Com.)