Methicillin-resistant Staphylococcus aureus (MRSA) ST398 in a farmer with skin lesions and in pigs of his farm: clonal relationship and detection of lnu(A) gene

Lozano, C. ; Aspiroz, C. ; Ara, M. (Universidad de Zaragoza) ; Gómez-Sanz, E. ; Zarazaga, M. ; Torres, C.

Resumen: Skin infection associated with methicillin-resistant Staphylococcus aureus (MRSA)-ST398 was detected in a pig-farmer, and MRSA-ST398 isolates were also detected in nasal samples of the patient and of 11/12 pigs on his farm. Twelve MRSA isolates were obtained from skin lesions (n = 6) and nasal samples (n = 6) of the patient in two sampling moments and 11 MRSA isolates from nasal samples of pigs. They were typed as t011-SCCmecIVa-agrI and t108-SCCmecV-agrI (patient and pigs) and t588-SCCmecV-agrI (patient). The following resistance genes were detected (number isolates): tet(K) (1), tet(L) (23), tet(M) (13), erm(A) (13), erm(C) (13), msr(A) (11), lnu(A) (21), aph(2′′)-acc(6′) (3), ant(4′) (13), aph(3′) (12), dfrS1 (15) and dfrK (22). Seventeen human and animal MRSA-ST398 isolates showed indistinguishable PFGE patterns (A1-spa-t011 or B2-spa-t108) and similar phenotypic-genotypic characteristics, including the presence of the lnu(A) gene, associated with lincomycin resistance. Potential pig-to-human transference of ST398 is suggested in this study. The first detection of the lnu(A) gene in MRSA-ST398 is reported.

Idioma: Inglés

DOI: 10.1111/j.1469-0691.2010.03437.x

Año: 2010

Publicado en: Clinical Microbiology and Infection 17, 6 (2010), 923-927
ISSN: 1198-743X

Factor impacto JCR: 4.784 (2010)

Categ. JCR: MICROBIOLOGY rank: 17 / 103 = 0.165 (2010) - Q1 - T1
Categ. JCR: INFECTIOUS DISEASES rank: 8 / 57 = 0.14 (2010) - Q1 - T1

Tipo y forma: Article (Published version)

Área (Departamento): Área Dermatología (Dpto. Medicina, Psiqu. y Derm.)