The revised-FINDRISC: A tool for type 2 diabetes risk screening across diverse populations incorporating sociodemographic indicators

Vitoratou, Dimitra-Irinna ; Dimakopoulou, Konstantina ; Mavrogianni, Christina ; Karaglani, Eva ; Argyropoulou, Matzourana ; Cardon, Greet ; Usheva, Natalya ; Iotova, Violeta ; Tankova, Tsvetalina ; Giménez-Legarre, Natalia ; Moreno, Luis A. (Universidad de Zaragoza) ; Toti, Florian ; Makrilakis, Konstantinos ; Doracaj, Ditila ; Imre, Rurik ; Torzsa, Péter ; Lindström, Jaana ; Panagiotakos, Demosthenes ; Manios, Yannis

Resumen: Aim
Τo develop a revised version of the FINDRISC tailored to improve the identification of individuals at high risk for type 2 diabetes (T2D) across diverse populations.
Methods
The revised-FINDRISC was developed using pooled harmonized baseline data from the multinational Feel4Diabetes (NCT02393872; N = 3526) and DigiCare4You (NCT05648383; N = 2156) studies. Validation utilized data from the 20-year ATTICA cohort study in Greece. Original FINDRISC components were analyzed using Fisher’s Linear Discriminant Analysis followed by supervised stepwise logistic regression to identify significant T2D cross-sectional predictors. The revised-FINDRISC was developed by re-scoring or excluding original items and incorporating new predictors, generating an integer-based score to enhance usability.
Results
The revised-FINDRISC significantly improved accuracy in identifying current T2D risk over the original, with an overall AUC of 0.911(95%CI: 0.901,0.922) versus 0.832(0.815,0.846). When stratified by country economic classification, the revised score outperformed the original across all groups: LMICs: 0.881(0.864,0.898) vs. 0.815(0.793,0.837), South European-HICs: 0.891(0.867,0.916) vs. 0.839(0.811,0.869), and North European-HICs: 0.921(0.872,0.971) vs. 0.844(0.742,0.949). A clinical threshold score of 13/24 in the revised-FINDRISC offers optimal sensitivity and specificity for identifying individuals at risk of T2D.
Conclusion
Enhanced with demographic, socio-economic, and clinical factors, the revised-FINDRISC potentially represents a substantive advancement in T2D screening, supporting early detection and targeted prevention.

Idioma: Inglés

DOI: 10.1016/j.annepidem.2026.110064

Año: 2026

Publicado en: ANNALS OF EPIDEMIOLOGY 117 (2026), 110064 [10 pp.]
ISSN: 1047-2797

Financiación: info:eu-repo/grantAgreement/EC/H2020/643708/EU/Developing and implementing a community-based intervention to create a more supportive social and physical environment for lifestyle changes to prevent diabetes in vulnerable families across Europe/Feel4Diabetes
Financiación: info:eu-repo/grantAgreement/EC/H2020/945246 /EU/An intersectoral innovative solution involving DIGItal tools, empowering families and integrating community CARE services for the prevention and management of type 2 diabetes and hypertension/DigiCare4You

Tipo y forma: Article (Published version)

Área (Departamento): Área Enfermería (Dpto. Fisiatría y Enfermería)