000170177 001__ 170177
000170177 005__ 20260407115449.0
000170177 0247_ $$2doi$$a10.3390/ijms27031309
000170177 0248_ $$2sideral$$a148715
000170177 037__ $$aART-2026-148715
000170177 041__ $$aeng
000170177 100__ $$0(orcid)0000-0002-8880-6580$$aSerrano-Casorrán, Carolina$$uUniversidad de Zaragoza
000170177 245__ $$aThe local damage and systemic inflammation induced by a biodegradable polydioxanone Stent implanted in the rabbit trachea decreases markedly with Stent degradation
000170177 260__ $$c2026
000170177 5060_ $$aAccess copy available to the general public$$fUnrestricted
000170177 5203_ $$aBiodegradable tracheal stents have been developed to overcome the limitations of metallic and removable stents in benign airway disease. This study evaluated the local and systemic inflammatory response induced by a biodegradable polydioxanone tracheal stent in a rabbit model. Twenty-one rabbits were assigned to three follow-up groups (30, 60, and 90 days). In each group, six animals received a tracheal stent, and one served as a sham control. Clinical status and respiratory symptoms were monitored, and serial peripheral blood interleukin-8 (IL-8) levels were measured. At the end of follow-up, tracheoscopy, IL-8 quantification in tracheal lavage, and necropsy were performed. No deaths or severe respiratory symptoms occurred. Tracheoscopic findings were significantly less severe after stent degradation, with reduced congestion (p = 0.030), inflammation (p = 0.003), and secretions (p = 0.030). Two granulomas and two cases of stenosis were identified. Mean IL-8 expression in tracheal lavage (relative quantification, RQ) was 14,129 ± 3007 when the stent was present and 426 ± 100 after degradation (p = 0.003). Blood IL-8 expression increased significantly on day 1 compared with baseline (p = 0.022) and subsequently decreased (p = 0.034). Inflammatory and structural alterations induced by a polydioxanone tracheal stent decrease after stent degradation.
000170177 536__ $$9info:eu-repo/grantAgreement/ES/DGA/B36-23R
000170177 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttps://creativecommons.org/licenses/by/4.0/deed.es
000170177 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000170177 700__ $$0(orcid)0000-0003-3880-3821$$aRodríguez-Zapater, Sergio
000170177 700__ $$aRodríguez-Panadero, Francisco
000170177 700__ $$aGómez, Raquel
000170177 700__ $$0(orcid)0000-0001-6178-9891$$aBonastre, Cristina$$uUniversidad de Zaragoza
000170177 700__ $$0(orcid)0000-0002-0113-5121$$aGuirola, José Andrés$$uUniversidad de Zaragoza
000170177 700__ $$0(orcid)0000-0001-9605-4959$$aRodríguez, José$$uUniversidad de Zaragoza
000170177 700__ $$0(orcid)0000-0002-5618-7519$$aGregorio, Miguel Ángel de$$uUniversidad de Zaragoza
000170177 7102_ $$11011$$2770$$aUniversidad de Zaragoza$$bDpto. Microb.Ped.Radio.Sal.Pú.$$cÁrea Radiol. y Medicina Física
000170177 7102_ $$11009$$2617$$aUniversidad de Zaragoza$$bDpto. Patología Animal$$cÁrea Medicina y Cirugía Animal
000170177 773__ $$g27, 3 (2026), 1309 [12 pp.]$$pInt. j. mol. sci.$$tInternational Journal of Molecular Sciences$$x1661-6596
000170177 8564_ $$s1980684$$uhttps://zaguan.unizar.es/record/170177/files/texto_completo.pdf$$yVersión publicada
000170177 8564_ $$s2369874$$uhttps://zaguan.unizar.es/record/170177/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000170177 909CO $$ooai:zaguan.unizar.es:170177$$particulos$$pdriver
000170177 951__ $$a2026-03-26-14:31:06
000170177 980__ $$aARTICLE