Atypical Melanosis on Acral Skin or Early Acral Lentiginous Melanoma? Reappraising an Ambiguous Concept in Acquired Acral Pigmented Lesions

Álvarez-Salafranca, Marcial (Universidad de Zaragoza) ; Gil-Pallares, Pedro ; Navarro-Bielsa, Alba ; Gracia-Cazaña, Tamara (Universidad de Zaragoza) ; Monteagudo, Carlos ; Gómez-Mateo, María Carmen (Universidad de Zaragoza)

Resumen: Acral lentiginous melanoma (ALM), first described by Reed et al. in 1976, is a histopathologic subtype of cutaneous melanoma (CM) that arises on the palms, soles, or within the nail apparatus. Although ALM represents only a small percentage of all CMs in populations predominantly of European descent, it is the most common subtype in most Latin American, African, and Asian countries, where other histopathologic variants are markedly underrepresented. The fact that these slow-growing tumors often develop in “hidden” locations and remain clinically subtle during their early stages hinders early clinical detection, likely contributing to their poorer overall prognosis compared to other CM subtypes...

Idioma: Inglés

DOI: 10.1111/cup.70097

Año: 2026

Publicado en: JOURNAL OF CUTANEOUS PATHOLOGY (2026), [7 pp.]
ISSN: 0303-6987

Tipo y forma: Article (Published version)

Área (Departamento): Área Dermatología (Dpto. Medicina, Psiqu. y Derm.)
Área (Departamento): Área Anatomía Patológica (Dpto. Cirugía)