One-pot stepwise and consecutive mechanistically incompatible solvent-free reactions: Synthetic and mechanistic insights
Cambronero-Arregui, Jorge ; Martínez, Alejandro V. ; Pires, Elisabet (Universidad de Zaragoza) ; Mayoral, José A. (Universidad de Zaragoza) ; Leal-Duaso, Alejandro
Resumen: Pd nanoparticles supported on an accessible laponite clay are efficient and highly recoverable catalytic systems in benchmark coupling and hydrogenation reactions under solvent-free conditions. In this paper, we explore the use of these supported catalytic systems in one-pot stepwise and consecutive reactions with excellent isolated yields. Whereas the catalyst recovered from hydrogenation reactions remains active in both coupling and hydrogenation processes, the catalyst used in coupling reactions is progressively deactivated for further hydrogenations. This behavior is not due neither to the nanoparticles agglomeration nor to Pd leaching, but to the formation of Pd(II) on the catalyst surface, disclosing a clear XPS evidence for the theory of the “release and capture” mechanism. Nonetheless, the hydrogenation activity is fully recovered after reducing this surface Pd(II) using ethanol. Finally, we have applied this strategy in the synthesis of products with practical pharmaceutical interest such as nabumetone and resveratrol.
Idioma: Inglés
DOI: 10.1016/j.jcat.2026.116860
Año: 2026
Publicado en: Journal of Catalysis 458 (2026), 116860 [11 pp.]
ISSN: 0021-9517
Financiación: info:eu-repo/grantAgreement/ES/DGA/E37-23R
Financiación: info:eu-repo/grantAgreement/ES/MINECO/PID2021-125762NB-I00
Tipo y forma: Article (Published version)
Área (Departamento): Área Química Orgánica (Dpto. Química Orgánica)
You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. You may not use the material for commercial purposes.
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Idioma: Inglés
DOI: 10.1016/j.jcat.2026.116860
Año: 2026
Publicado en: Journal of Catalysis 458 (2026), 116860 [11 pp.]
ISSN: 0021-9517
Financiación: info:eu-repo/grantAgreement/ES/DGA/E37-23R
Financiación: info:eu-repo/grantAgreement/ES/MINECO/PID2021-125762NB-I00
Tipo y forma: Article (Published version)
Área (Departamento): Área Química Orgánica (Dpto. Química Orgánica)
You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. You may not use the material for commercial purposes. Exportado de SIDERAL (2026-04-18-10:49:35)
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Record created 2026-04-18, last modified 2026-04-20