000171162 001__ 171162
000171162 005__ 20260515163945.0
000171162 0247_ $$2doi$$a10.3390/covid6040060
000171162 0248_ $$2sideral$$a149290
000171162 037__ $$aART-2026-149290
000171162 041__ $$aeng
000171162 100__ $$aLlana, Tania
000171162 245__ $$aSpatial Memory and COVID-19: Cognitive Patterns, Assessment Approaches, and Neural Substrates
000171162 260__ $$c2026
000171162 5060_ $$aAccess copy available to the general public$$fUnrestricted
000171162 5203_ $$aCOVID-19 is increasingly recognized as a multisystemic disease with significant neurocognitive consequences. However, its specific impact on spatial memory, a cognitive domain essential for daily navigation and functional independence, remains insufficiently explored. This narrative review provides a critical synthesis of current evidence regarding spatial and visuospatial memory alterations across acute and post-acute phases, and post COVID-19 condition (PCC). Clinical findings, conventional and emerging assessment tools ranging from static tasks to immersive virtual reality environments, as well as potential neurobiological mechanisms, were considered. Results suggested that spatial memory is frequently compromised after COVID-19 disease, with deficits being most pronounced at longer retention intervals and within navigational contexts. Neuroimaging and biomarker data further reveal selective vulnerability in the medial temporal lobe, characterized by hippocampal atrophy, hypoperfusion, and disrupted functional connectivity. Importantly, traditional neuropsychological tools may underestimate these impairments due to limited ecological validity. Therefore, implementing multimodal assessment frameworks that integrate navigational paradigms is essential to enhance diagnostic sensitivity and facilitate the development of targeted rehabilitation strategies for PCC patients.
000171162 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttps://creativecommons.org/licenses/by/4.0/deed.es
000171162 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000171162 700__ $$0(orcid)0000-0001-6285-8158$$aGarces-Arilla, Sara$$uUniversidad de Zaragoza
000171162 700__ $$aMendez, Marta
000171162 7102_ $$14009$$2620$$aUniversidad de Zaragoza$$bDpto. Psicología y Sociología$$cÁrea Metod.Ciencias Comportam.
000171162 773__ $$g6, 4 (2026), 60 [23 pp.]$$pCOVID$$tCOVID$$x2673-8112
000171162 8564_ $$s1311938$$uhttps://zaguan.unizar.es/record/171162/files/texto_completo.pdf$$yVersión publicada
000171162 8564_ $$s2359499$$uhttps://zaguan.unizar.es/record/171162/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000171162 909CO $$ooai:zaguan.unizar.es:171162$$particulos$$pdriver
000171162 951__ $$a2026-05-15-14:54:10
000171162 980__ $$aARTICLE