Xenobiotics that affect oxidative phosphorylation alter differentiation of human adipose-derived stem cells at concentrations that are found in human blood

Llobet, Laura (Universidad de Zaragoza) ; Toivonen, Janne M (Universidad de Zaragoza) ; Montoya, Julio (Universidad de Zaragoza) ; Ruiz-Pesini, Eduardo (Universidad de Zaragoza) ; López-Gallardo, Ester (Universidad de Zaragoza)

Resumen: Adipogenesis is accompanied by differentiation of adipose tissuederived stem cells to adipocytes. As part of this differentiation, biogenesis of the oxidative phosphorylation system occurs. Many chemical compounds used in medicine, agriculture or other human activities affect oxidative phosphorylation function. Therefore, these xenobiotics could alter adipogenesis. We have analyzed the effects on adipocyte differentiation of some xenobiotics that act on the oxidative phosphorylation system. The tested concentrations have been previously reported in human blood. Our results show that pharmaceutical drugs that decrease mitochondrial DNA replication, such as nucleoside reverse transcriptase inhibitors, or inhibitors of mitochondrial protein synthesis, such as ribosomal antibiotics, diminish adipocyte differentiation and leptin secretion. By contrast, the environmental chemical pollutant tributyltin chloride, which inhibits the ATP synthase of the oxidative phosphorylation system, can promote adipocyte differentiation and leptin secretion, leading to obesity and metabolic syndrome as postulated by the obesogen hypothesis.

Idioma: Inglés

DOI: 10.1242/dmm.021774

Año: 2015

Publicado en: Disease Models & Mechanisms 8 (2015), 1441-1455
ISSN: 1754-8403

Factor impacto JCR: 4.316 (2015)

Categ. JCR: PATHOLOGY rank: 10 / 79 = 0.127 (2015) - Q1 - T1
Categ. JCR: CELL BIOLOGY rank: 59 / 187 = 0.316 (2015) - Q2 - T1

Factor impacto SCIMAGO: 2.712 - Biochemistry, Genetics and Molecular Biology (miscellaneous) (Q1) - Neuroscience (miscellaneous) (Q1) - Medicine (miscellaneous) (Q1) - Immunology and Microbiology (miscellaneous) (Q1)

Financiación: info:eu-repo/grantAgreement/ES/FIS/PI14-00005
Financiación: info:eu-repo/grantAgreement/ES/FIS/PI14-00070
Financiación: info:eu-repo/grantAgreement/ES/IACS/PIPAMER-09-01
Financiación: info:eu-repo/grantAgreement/ES/IACS/PIPAMER-10-010

Tipo y forma: Article (Published version)

Área (Departamento): Área Genética (Dpto. Anatom.,Embri.Genét.Ani.)
Área (Departamento): Area Histología (Dpto. Anatom.Histolog.Humanas)
Área (Departamento): Área Bioquímica y Biolog.Mole. (Dpto. Bioq.Biolog.Mol. Celular)