Kinetic theory modeling and efficient numerical simulation of gene regulatory networks based on qualitative descriptions
Resumen: n this work, we begin by considering the qualitative modeling of biological regulatory systems using process hitting, from which we define its probabilistic counterpart by considering the chemical master equation within a kinetic theory framework. The last equation is efficiently solved by considering a separated representation within the proper generalized decomposition framework that allows circumventing the so-called curse of dimensionality. Finally, model parameters can be added as extra-coordinates in order to obtain a parametric solution of the model
Idioma: Inglés
DOI: 10.3390/e17041896
Año: 2015
Publicado en: ENTROPY 17, 4 (2015), 1896-1915
ISSN: 1099-4300

Factor impacto JCR: 1.743 (2015)
Categ. JCR: PHYSICS, MULTIDISCIPLINARY rank: 25 / 78 = 0.321 (2015) - Q2 - T1
Factor impacto SCIMAGO:

Tipo y forma: Article (Published version)
Área (Departamento): Mec. de Medios Contínuos y Teor. de Estructuras (Departamento de Ingeniería Mecánica)

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Exportado de SIDERAL (2017-05-04-09:05:27)

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Articles > Artículos por área > Mec. de Medios Contínuos y Teor. de Estructuras

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