Página principal > Artículos > Kinetic theory modeling and efficient numerical simulation of gene regulatory networks based on qualitative descriptions
Resumen: n this work, we begin by considering the qualitative modeling of biological regulatory systems using process hitting, from which we define its probabilistic counterpart by considering the chemical master equation within a kinetic theory framework. The last equation is efficiently solved by considering a separated representation within the proper generalized decomposition framework that allows circumventing the so-called curse of dimensionality. Finally, model parameters can be added as extra-coordinates in order to obtain a parametric solution of the model Idioma: Inglés DOI: 10.3390/e17041896 Año: 2015 Publicado en: ENTROPY 17, 4 (2015), 1896-1915 ISSN: 1099-4300 Factor impacto JCR: 1.743 (2015) Categ. JCR: PHYSICS, MULTIDISCIPLINARY rank: 25 / 79 = 0.316 (2015) - Q2 - T1 Factor impacto SCIMAGO: 0.551 - Physics and Astronomy (miscellaneous) (Q2)