New perspectives in the search for reliable biomarkers in alzheimer disease

Moreno, L. (Universidad de Zaragoza) ; Osta, R. (Universidad de Zaragoza) ; Calvo, A.C. (Universidad de Zaragoza)

Resumen: Background and Objectives: The search for accurate biomarkers in Alzheimer Disease (AD), on of the most devastating neurodegenerative diseases, remains essential to enable an early prognosis and diagnosis of the disease and to provide more efficient ther- apeutic strategies.
A wide variety of potential biomarkers are has been identified by neuroimaging tech- niques and by the analysis of fluid samples, such as cerebrospinal fluid (CSF) or blood. Recently, a growing number of studies are focused on the discovery of reliable blood- based biomarkers in blood, especially in the prodromal stage of AD, which can predict the conversion of asymptomatic cases to AD demented cases.
In this review, the latest challenges in the search for accurate biomarkers of AD is re- vised, in particular, an update in blood-based biomarkers is described in depth.
Conclusions: Finally, the close link among AD and other neurodegenerative diseases is discussed, mainly based on the last discovered mutation, the chromosome 9 open reading frame 72, C9ORF72.

Idioma: Inglés

DOI: 10.4321/S0213-61632015000100005

Año: 2015

Publicado en: European Journal of Psychiatry 29, 1 (2015), 51 - 65
ISSN: 0213-6163

Originalmente disponible en: Texto completo de la revista

Factor impacto JCR: 0.711 (2015)

Categ. JCR: PSYCHIATRY rank: 121 / 139 = 0.871 (2015) - Q4 - T3

Factor impacto SCIMAGO: 0.309 - Psychiatry and Mental Health (Q3)

Financiación: info:eu-repo/grantAgreement/ES/FIS/PI10-0178

Tipo y forma: Article (Published version)

Área (Departamento): Área Genética (Dpto. Anatom.,Embri.Genét.Ani.)