Regulation of mouse retroelement MuERV-L/MERVL expression by REX1 and epigenetic control of stem cell potency
Resumen: About half of the mammalian genome is occupied by DNA sequences that originate from transposable elements. Retrotransposons can modulate gene expression in different ways and, particularly retrotransposon-derived long terminal repeats, profoundly shape expression of both surrounding and distant genomic loci. This is especially important in pre-implantation development, during which extensive reprograming of the genome takes place and cells pass through totipotent and pluripotent states. At this stage, the main mechanism responsible for retrotransposon silencing, i.e., DNA methylation, is inoperative. A particular retrotransposon called muERV-L/MERVL is expressed during pre-implantation stages and contributes to the plasticity of mouse embryonic stem cells. This review will focus on the role of MERVL-derived sequences as controlling elements of gene expression specific for pre-implantation development, two-cell stage-specific gene expression, and stem cell pluripotency, the epigenetic mechanisms that control their expression, and the contributions of the pluripotency marker REX1 and the related Yin Yang 1 family of transcription factors to this regulation process.
Idioma: Inglés
DOI: 10.3389/fonc.2014.00014
Año: 2014
Publicado en: Frontiers in Oncology 4 (2014), A.14 [18 p.]
ISSN: 2234-943X

Factor impacto SCIMAGO:

Financiación: info:eu-repo/grantAgreement/ES/DGA/PI110-09
Financiación: info:eu-repo/grantAgreement/ES/FIS/PI07119
Tipo y forma: Article (Published version)
Área (Departamento): Anatomía y Anatomía Patológica Comparadas (Departamento de Anatomía, Embriología y Genética Animal)
Exportado de SIDERAL (2016-07-14-10:19:44)

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articulos > articulos-por-area > anatomia_y_anatomia_patologica_comparadas

 Notice créée le 2016-03-18, modifiée le 2017-03-27

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