Direct infussion Electrospray Mass Spectrometry as a new non-invasive tool for serum metabolomics in induced-stress subjects
Lorenzo-Tejedor, Mónica ; De la Cámara, Concepción (Universidad de Zaragoza) ; Lopez-Anton, Raúl (Universidad de Zaragoza) ; Bailón Luesma, Raquel (Universidad de Zaragoza) ; Aguiló, Jordi ; Bernal Ruiz, María Luisa (Universidad de Zaragoza)
Resumen: Background and Objectives: Nanotechnology is becoming a tool for the study of changes in the metabolome of patients in different states of disease. Analytical techniques such as Electrospray Mass Spectrometry, allow to find biomarkers by determi- nation of metabolites. Nowadays, there is not an objective analytical approach for diagno- sis of stress. Thus, the objectives of this pilot work are:
– Describing the development of a fast, direct and non-invasive analytical protocol, ap- plied for the first time, to study the metabolomic profile of patient s different states through a disease.
– Testing the protocol in a pilot sample with non-stressed and stress-induced subjects.
Methods: High resolution direct infusion electrospray mass spectrometry has been used to analyse the metabolome of blood samples (0.3 ml) from six subject s.
Results: Data prove a clear discrimination between non-stressed and stressed states in the metabolome. Data showed different predominant metabolites in both states. Results allow objective characterization of the state of the patient.
Conclusions: Although this is a pilot study, the method was successful in discriminating different metabolites in non-stressed and stress-induced subjects.
Idioma: Inglés
Año: 2015
Publicado en: European Journal of Psychiatry 29, 4 (2015), 259-275
ISSN: 0213-6163
Factor impacto JCR: 0.711 (2015)
Categ. JCR: PSYCHIATRY rank: 121 / 139 = 0.871 (2015) - Q4 - T3
Factor impacto SCIMAGO: 0.309 - Psychiatry and Mental Health (Q3)
Tipo y forma: Article (Published version)
Área (Departamento): Área Psicología Básica (Dpto. Psicología y Sociología)
Área (Departamento): Área Farmacología (Dpto. Farmacología y Fisiolog.)
Área (Departamento): Area Psiquiatría (Dpto. Medicina, Psiqu. y Derm.)
Área (Departamento): Área Teoría Señal y Comunicac. (Dpto. Ingeniería Electrón.Com.)
You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
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– Describing the development of a fast, direct and non-invasive analytical protocol, ap- plied for the first time, to study the metabolomic profile of patient s different states through a disease.
– Testing the protocol in a pilot sample with non-stressed and stress-induced subjects.
Methods: High resolution direct infusion electrospray mass spectrometry has been used to analyse the metabolome of blood samples (0.3 ml) from six subject s.
Results: Data prove a clear discrimination between non-stressed and stressed states in the metabolome. Data showed different predominant metabolites in both states. Results allow objective characterization of the state of the patient.
Conclusions: Although this is a pilot study, the method was successful in discriminating different metabolites in non-stressed and stress-induced subjects.
Idioma: Inglés
Año: 2015
Publicado en: European Journal of Psychiatry 29, 4 (2015), 259-275
ISSN: 0213-6163
Factor impacto JCR: 0.711 (2015)
Categ. JCR: PSYCHIATRY rank: 121 / 139 = 0.871 (2015) - Q4 - T3
Factor impacto SCIMAGO: 0.309 - Psychiatry and Mental Health (Q3)
Tipo y forma: Article (Published version)
Área (Departamento): Área Psicología Básica (Dpto. Psicología y Sociología)
Área (Departamento): Área Farmacología (Dpto. Farmacología y Fisiolog.)
Área (Departamento): Area Psiquiatría (Dpto. Medicina, Psiqu. y Derm.)
Área (Departamento): Área Teoría Señal y Comunicac. (Dpto. Ingeniería Electrón.Com.)
You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. Exportado de SIDERAL (2021-01-21-10:49:08)
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Record created 2016-05-06, last modified 2021-01-21