Control strategies of 3-cell Central Pattern Generator via global stimuli
Resumen: The study of the synchronization patterns of small neuron networks that control several biological processes has become an interesting growing discipline. Some of these synchronization patterns of individual neurons are related to some undesirable neurological diseases, and they are believed to play a crucial role in the emergence of pathological rhythmic brain activity in different diseases, like Parkinson''s disease. We show how, with a suitable combination of short and weak global inhibitory and excitatory stimuli over the whole network, we can switch between different stable bursting patterns in small neuron networks (in our case a 3-neuron network). We develop a systematic study showing and explaining the effects of applying the pulses at different moments. Moreover, we compare the technique on a completely symmetric network and on a slightly perturbed one (a much more realistic situation). The present approach of using global stimuli may allow to avoid undesirable synchronization patterns with nonaggressive stimuli.
Idioma: Inglés
DOI: 10.1038/srep23622
Año: 2016
Publicado en: SCIENTIFIC REPORTS 6 (2016), 23622 [10 pp]
ISSN: 2045-2322

Factor impacto JCR: 4.259 (2016)
Categ. JCR: MULTIDISCIPLINARY SCIENCES rank: 10 / 63 = 0.159 (2016) - Q1 - T1
Factor impacto SCIMAGO: 1.691 - Multidisciplinary (Q1)

Financiación: info:eu-repo/grantAgreement/ES/DGA/E15
Financiación: info:eu-repo/grantAgreement/ES/DGA/E48
Financiación: info:eu-repo/grantAgreement/ES/MICINN/MTM2012-31883
Financiación: info:eu-repo/grantAgreement/ES/MICINN/MTM2013-46337-C2-2-P
Financiación: info:eu-repo/grantAgreement/ES/MICINN/MTM2015-64095-P
Financiación: info:eu-repo/grantAgreement/ES/UZ/CUD2015-CIE-05
Tipo y forma: Article (Published version)
Área (Departamento): Área Matemática Aplicada (Dpto. Matemática Aplicada)

Creative Commons You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.


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