A controlled antibiotic release system to prevent orthopedic-implant associated infections: An in vitro study

Gimeno, M. ; Pinczowski, P. ; Pérez, M. (Universidad de Zaragoza) ; Giorello, A. ; Martínez, M.Á. (Universidad de Zaragoza) ; Santamaría, J. (Universidad de Zaragoza) ; Arruebo, M. (Universidad de Zaragoza) ; Luján, L. (Universidad de Zaragoza)

Resumen: A new device for local delivery of antibiotics is presented, with potential use as a drug-eluting fixation pin for orthopedic applications. The implant consists of a stainless steel hollow tubular reservoir packed with the desired antibiotic. Release takes place through several orifices previously drilled in the reservoir wall, a process that does not compromise the mechanical properties required for the implant. Depending on the antibiotic chosen and the number of orifices, the release profile can be tailored from a rapid release of the load (ca. 20 h) to a combination of rapid initial release and slower, sustained release for a longer period of time (ca. 200 h). An excellent bactericidal action is obtained, with 4-log reductions achieved in as little as 2 h, and total bacterial eradication in 8 h using 6-pinholed implants filled with cefazolin.

Idioma: Inglés

DOI: 10.1016/j.ejpb.2015.08.007

Año: 2015

Publicado en: European Journal of Pharmaceutics and Biopharmaceutics 96 (2015), 264-271
ISSN: 0939-6411

Factor impacto JCR: 3.975 (2015)

Categ. JCR: PHARMACOLOGY & PHARMACY rank: 44 / 255 = 0.173 (2015) - Q1 - T1

Factor impacto SCIMAGO: 1.437 - Biotechnology (Q1) - Pharmaceutical Science (Q1) - Medicine (miscellaneous) (Q1)

Financiación: info:eu-repo/grantAgreement/EC/FP7/614715/EU/A Photo-triggered On-demand Drug Delivery System for Chronic Pain/NANOHEDONISM

Tipo y forma: Article (Published version)

Área (Departamento): Área Anatom.Anatom.Patológ.Com (Dpto. Anatom.,Embri.Genét.Ani.)
Área (Departamento): Área Sanidad Animal (Dpto. Patología Animal)
Área (Departamento): Área Ingeniería Química (Dpto. Ing.Quím.Tecnol.Med.Amb.)
Área (Departamento): Área Mec.Med.Cont. y Teor.Est. (Dpto. Ingeniería Mecánica)