Resumen: Aim: To evaluate the efficacy and safety of glaucoma drainage device Ex-PRESS® P-50 for combined cataract surgery and glaucoma. Methods: Patients having cataract and open angle glaucoma or patients with open advanced glaucoma which needed two or more antiglaucoma medications were included. Combined cataract surgery and glaucoma with Ex-PRESS® P-50 model placed under scleral flap was performed. Results: Out of 40 eyes of 40 patients (55% male and 45% female) completed the study during one-year follow-up. The mean of age was 76.6±11.02y. The intraocular pressure (IOP) decreased significantly during the 12-month follow-up from 23.5 mm Hg to 16.8 mm Hg (Wilcoxon signed ranks test, P<0.001). A 59.5% of patients did not need any topical treatment, 10.8% of them needed one active principle, 27% needed two active principles, and 2.7% of them needed three active principles for successful IOP control (<21 mm Hg). Conclusion: Combined surgery of phacoemulsification with ExPRESS® P-50 lowers IOP from the preoperative baseline and reduces significantly the number of antiglaucoma active principles for IOP control after the operation. Idioma: Inglés DOI: 10.18240/ijo.2016.04.11 Año: 2016 Publicado en: INTERNATIONAL JOURNAL OF OPHTHALMOLOGY 9, 4 (2016), 546-550 ISSN: 2222-3959 Factor impacto JCR: 1.177 (2016) Categ. JCR: OPHTHALMOLOGY rank: 50 / 59 = 0.847 (2016) - Q4 - T3 Factor impacto SCIMAGO: 0.604 - Ophthalmology (Q2)