000056231 001__ 56231
000056231 005__ 20210121114544.0
000056231 0247_ $$2doi$$a10.1038/srep07988
000056231 0248_ $$2sideral$$a95416
000056231 037__ $$aART-2015-95416
000056231 041__ $$aeng
000056231 100__ $$0(orcid)0000-0002-1232-6310$$aVega, S.
000056231 245__ $$aDeconvolution analysis for classifying gastric adenocarcinoma patients based on differential scanning calorimetry serum thermograms
000056231 260__ $$c2015
000056231 5060_ $$aAccess copy available to the general public$$fUnrestricted
000056231 5203_ $$aRecently, differential scanning calorimetry (DSC) has been acknowledged as a novel tool for diagnosing and monitoring several diseases. This highly sensitive technique has been traditionally used to study thermally induced protein folding/unfolding transitions. In previous research papers, DSC profiles from blood samples of patients were analyzed and they exhibited marked differences in the thermal denaturation profile. Thus, we investigated the use of this novel technology in blood serum samples from 25 healthy subjects and 30 patients with gastric adenocarcinoma (GAC) at different stages of tumor development with a new multiparametric approach. The analysis of the calorimetric profiles of blood serum from GAC patients allowed us to discriminate three stages of cancer development (I to III) from those of healthy individuals. After a multiparametric analysis, a classification of blood serum DSC parameters from patients with GAC is proposed. Certain parameters exhibited significant differences (P < 0.05) and allowed the discrimination of healthy subjects/patients from patients at different tumor stages. The results of this work validate DSC as a novel technique for GAC patient classification and staging, and offer new graphical tools and value ranges for the acquired parameters in order to discriminate healthy from diseased subjects with increased disease burden.
000056231 536__ $$9info:eu-repo/grantAgreement/ES/MICINN/BFU2010-19451$$9info:eu-repo/grantAgreement/ES/MICINN/PTA2009-2341-I
000056231 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000056231 590__ $$a5.228$$b2015
000056231 591__ $$aMULTIDISCIPLINARY SCIENCES$$b7 / 62 = 0.113$$c2015$$dQ1$$eT1
000056231 592__ $$a2.034$$b2015
000056231 593__ $$aMultidisciplinary$$c2015$$dQ1
000056231 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000056231 700__ $$aGarcia-Gonzalez, M.
000056231 700__ $$0(orcid)0000-0001-5932-2889$$aLanas, A.$$uUniversidad de Zaragoza
000056231 700__ $$0(orcid)0000-0001-5702-4538$$aVelazquez-Campoy, A.$$uUniversidad de Zaragoza
000056231 700__ $$0(orcid)0000-0001-5664-1729$$aAbian, O.
000056231 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000056231 7102_ $$11002$$2060$$aUniversidad de Zaragoza$$bDpto. Bioq.Biolog.Mol. Celular$$cÁrea Bioquímica y Biolog.Mole.
000056231 773__ $$g5 (2015), 07988 [8 p.]$$pSci. rep.$$tScientific Reports$$x2045-2322
000056231 8564_ $$s1180978$$uhttps://zaguan.unizar.es/record/56231/files/texto_completo.pdf$$yPostprint
000056231 8564_ $$s102574$$uhttps://zaguan.unizar.es/record/56231/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000056231 909CO $$ooai:zaguan.unizar.es:56231$$particulos$$pdriver
000056231 951__ $$a2021-01-21-11:17:48
000056231 980__ $$aARTICLE