000056678 001__ 56678
000056678 005__ 20220831095640.0
000056678 0247_ $$2doi$$a10.1136/bmjopen-2015-009658
000056678 0248_ $$2sideral$$a95780
000056678 037__ $$aART-2016-95780
000056678 041__ $$aeng
000056678 100__ $$0(orcid)0000-0002-1402-3129$$aPolo, V.$$uUniversidad de Zaragoza
000056678 245__ $$aVisual dysfunction and its correlation with retinal changes in patients with Parkinson’ s disease: an observational cross-sectional study
000056678 260__ $$c2016
000056678 5060_ $$aAccess copy available to the general public$$fUnrestricted
000056678 5203_ $$aObjectives: To evaluate visual dysfunction and its correlation with structural changes in the retina in patients with Parkinson’s disease (PD).
Methods: Patients with PD (n=37) and controls (n=37) were included in an observational cross- sectional study, and underwent visual acuity (VA), colour vision (using the Farnsworth and Lanthony desaturated D15 colour tests) and contrast sensitivity vision (CSV; using the Pelli-Robson chart and CSV 1000E test) evaluation to measure visual dysfunction. Structural measurements of the retinal nerve fibre layer (RNFL), and macular and ganglion cell layer (GCL) thicknesses, were obtained using spectral domain optical coherence tomography (SD-OCT). Comparison of obtained data, and correlation analysis between functional and structural results were performed. Results: VA (in all different contrast levels) and all CSV spatial frequencies were significantly worse in patients with PD than in controls. Colour vision was significantly affected based on the Lanthony colour test. Significant GCL loss was observed in the minimum GCL+inner plexiform layer. A clear tendency towards a reduction in several macular sectors (central, outer inferior, outer temporal and superior (inner and outer)) and in the temporal quadrant of the RNFL thickness was observed, although the difference was not significant. CSV was the functional parameter most strongly correlated with structural measurements in PD. Colour vision was associated with most GCL measurements. Macular thickness was strongly correlated with macular volume and functional parameters (r>0.70, p<0.05).
Conclusions: Patients with PD had visual dysfunction that correlated with structural changes evaluated by SD-OCT. GCL measurements may be reliable indicators of visual impairment in patients with PD.
000056678 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc$$uhttp://creativecommons.org/licenses/by-nc/3.0/es/
000056678 590__ $$a20.785$$b2016
000056678 591__ $$aMEDICINE, GENERAL & INTERNAL$$b4 / 154 = 0.026$$c2016$$dQ1$$eT1
000056678 592__ $$a2.926$$b2016
000056678 593__ $$aMedicine (miscellaneous)$$c2016$$dQ1
000056678 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000056678 700__ $$0(orcid)0000-0002-1609-5994$$aSatue, M.
000056678 700__ $$aRodrigo, MJ.
000056678 700__ $$0(orcid)0000-0002-6591-0801$$aOtin, S.$$uUniversidad de Zaragoza
000056678 700__ $$aAlarcia, R.
000056678 700__ $$0(orcid)0000-0001-5320-7839$$aBambo, MP.
000056678 700__ $$0(orcid)0000-0002-4316-1635$$aFuertes, MI.$$uUniversidad de Zaragoza
000056678 700__ $$0(orcid)0000-0002-6745-7668$$aLarrosa, JM.$$uUniversidad de Zaragoza
000056678 700__ $$0(orcid)0000-0003-2389-8282$$aPablo, LE.$$uUniversidad de Zaragoza
000056678 700__ $$0(orcid)0000-0001-6258-2489$$aGarcia-Martin, E.$$uUniversidad de Zaragoza
000056678 7102_ $$11004$$2646$$aUniversidad de Zaragoza$$bDpto. Cirugía,Ginecol.Obstetr.$$cÁrea Oftalmología
000056678 7102_ $$12002$$2647$$aUniversidad de Zaragoza$$bDpto. Física Aplicada$$cÁrea Óptica
000056678 773__ $$g6 (2016), e009658 [9 pp.]$$pBMJ, Br. med. j.$$tBRITISH MEDICAL JOURNAL$$x0959-8146
000056678 8564_ $$s870754$$uhttps://zaguan.unizar.es/record/56678/files/texto_completo.pdf$$yVersión publicada
000056678 8564_ $$s36425$$uhttps://zaguan.unizar.es/record/56678/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
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000056678 951__ $$a2022-08-31-09:48:01
000056678 980__ $$aARTICLE