000057808 001__ 57808
000057808 005__ 20170327111858.0
000057808 0247_ $$2doi$$a10.3390/ijms15011590
000057808 0248_ $$2sideral$$a84476
000057808 037__ $$aART-2014-84476
000057808 041__ $$aeng
000057808 100__ $$aGiannaccini, Martina
000057808 245__ $$aMagnetic Nanoparticles as Intraocular Drug Delivery System to Target Retinal Pigmented Epithelium (RPE)
000057808 260__ $$c2014
000057808 5060_ $$aAccess copy available to the general public$$fUnrestricted
000057808 5203_ $$aOne of the most challenging efforts in drug delivery is the targeting of the eye. The eye structure and barriers render this organ poorly permeable to drugs. Quite recently the entrance of nanoscience in ocular drug delivery has improved the penetration and half-life of drugs, especially in the anterior eye chamber, while targeting the posterior chamber is still an open issue. The retina and the retinal pigment epithelium/choroid tissues, located in the posterior eye chamber, are responsible for the majority of blindness both in childhood and adulthood. In the present study, we used magnetic nanoparticles (MNPs) as a nanotool for ocular drug delivery that is capable of specific localization in the retinal pigmented epithelium (RPE) layer. We demonstrate that, following intraocular injection in Xenopus embryos, MNPs localize specifically in RPE where they are retained for several days. The specificity of the localization did not depend on particle size and surface properties of the MNPs used in this work. Moreover, through similar experiments in zebrafish, we demonstrated that the targeting of RPE by the nanoparticles is not specific for the Xenopus species.
000057808 536__ $$9info:eu-repo/grantAgreement/ES/MINECO/MAT2010-19326
000057808 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000057808 590__ $$a2.862$$b2014
000057808 591__ $$aCHEMISTRY, MULTIDISCIPLINARY$$b45 / 154 = 0.292$$c2014$$dQ2$$eT1
000057808 591__ $$aBIOCHEMISTRY & MOLECULAR BIOLOGY$$b134 / 289 = 0.464$$c2014$$dQ2$$eT2
000057808 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000057808 700__ $$aGiannini, Marianna
000057808 700__ $$0(orcid)0000-0001-9359-0019$$aCalatayud, M. Pilar
000057808 700__ $$0(orcid)0000-0003-1558-9279$$aGoya, Gerardo F.$$uUniversidad de Zaragoza
000057808 700__ $$aCuschieri, Alfred
000057808 700__ $$aDente, Luciana
000057808 700__ $$aRaffa, Vittoria
000057808 7102_ $$12003$$2395$$aUniversidad de Zaragoza$$bDepartamento de Física de la Materia Condensada$$cFísica de la Materia Condensada
000057808 773__ $$g15 (2014), 1590-1605$$pInt. j. mol. sci.$$tINTERNATIONAL JOURNAL OF MOLECULAR SCIENCES$$x1661-6596
000057808 8564_ $$s1091927$$uhttps://zaguan.unizar.es/record/57808/files/texto_completo.pdf$$yVersión publicada
000057808 8564_ $$s91921$$uhttps://zaguan.unizar.es/record/57808/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000057808 909CO $$ooai:zaguan.unizar.es:57808$$particulos$$pdriver
000057808 951__ $$a2016-12-13-12:55:03
000057808 980__ $$aARTICLE