Effect of oral anticoagulants on the outcome of faecal immunochemical test
Resumen: Background:
We aimed to evaluate whether oral anticoagulants (OACs) alter faecal immunochemical test (FIT) performance in average-risk colorectal cancer (CRC) screening.
Individuals aged 50–69 years were invited to receive one FIT sample (cutoff 75¿ng¿ml–1) between November 2008 and June 2011.
Faecal immunochemical test was positive in 9.3% (21 out of 224) of users of OAC and 6.2% (365 out of 5821) of non-users (P-trend=0.07). The positive predictive value (PPV) for advanced neoplasia (AN) in non-users was 50.4% vs 47.6% in users (odds ratio, 0.70; 95% CI, 0.3–1.8; P=0.5). The PPV for AN in OAC more antiplatelets (aspirin or clopidogrel) was 75% (odds ratio, 2; 95% CI, 0.4–10.8; P=0.4).
Oral anticoagulant did not significantly modify the PPV for AN in this population-based colorectal screening program. The detection rate of advanced adenoma was higher in the combination OAC more antiplatelets.

Idioma: Inglés
DOI: 10.1038/bjc.2014.38
Año: 2014
Publicado en: BRITISH JOURNAL OF CANCER 110, 5 (2014), 1334-1337
ISSN: 0007-0920

Factor impacto JCR: 4.836 (2014)
Categ. JCR: ONCOLOGY rank: 34 / 209 = 0.163 (2014) - Q1 - T1
Factor impacto SCIMAGO:

Financiación: info:eu-repo/grantAgreement/ES/ISCIII/PI08-90717
Tipo y forma: Article (Published version)
Área (Departamento): Medicina (Departamento de Medicina, Psiquiatría y Dermatología)

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Exportado de SIDERAL (2017-05-03-13:43:44)

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 Record created 2016-12-14, last modified 2017-05-03

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