Effect of oral anticoagulants on the outcome of faecal immunochemical test
Resumen: Background:
We aimed to evaluate whether oral anticoagulants (OACs) alter faecal immunochemical test (FIT) performance in average-risk colorectal cancer (CRC) screening.
Methods:
Individuals aged 50–69 years were invited to receive one FIT sample (cutoff 75¿ng¿ml–1) between November 2008 and June 2011.
Results:
Faecal immunochemical test was positive in 9.3% (21 out of 224) of users of OAC and 6.2% (365 out of 5821) of non-users (P-trend=0.07). The positive predictive value (PPV) for advanced neoplasia (AN) in non-users was 50.4% vs 47.6% in users (odds ratio, 0.70; 95% CI, 0.3–1.8; P=0.5). The PPV for AN in OAC more antiplatelets (aspirin or clopidogrel) was 75% (odds ratio, 2; 95% CI, 0.4–10.8; P=0.4).
Conclusions:
Oral anticoagulant did not significantly modify the PPV for AN in this population-based colorectal screening program. The detection rate of advanced adenoma was higher in the combination OAC more antiplatelets.

Idioma: Inglés
DOI: 10.1038/bjc.2014.38
Año: 2014
Publicado en: BRITISH JOURNAL OF CANCER 110, 5 (2014), 1334-1337
ISSN: 0007-0920

Factor impacto JCR: 4.836 (2014)
Categ. JCR: ONCOLOGY rank: 34 / 209 = 0.163 (2014) - Q1 - T1
Factor impacto SCIMAGO:

Financiación: info:eu-repo/grantAgreement/ES/ISCIII/PI08-90717
Tipo y forma: Article (Published version)
Área (Departamento): Medicina (Departamento de Medicina, Psiquiatría y Dermatología)

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Exportado de SIDERAL (2017-05-03-13:43:44)

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