000057916 001__ 57916 000057916 005__ 20201023135857.0 000057916 0247_ $$2doi$$a10.1155/2014/652817 000057916 0248_ $$2sideral$$a86878 000057916 037__ $$aART-2014-86878 000057916 041__ $$aeng 000057916 100__ $$0(orcid)0000-0003-0156-4230$$aOliván, S.$$uUniversidad de Zaragoza 000057916 245__ $$aSex differences in constitutive autophagy 000057916 260__ $$c2014 000057916 5060_ $$aAccess copy available to the general public$$fUnrestricted 000057916 5203_ $$aSex bias has been described nowadays in biomedical research on animal models, although sexual dimorphism has been confirmed widely under pathological and physiological conditions. The main objective of our work was to study the sex differences in constitutive autophagy in spinal cord and skeletalmuscle tissue fromwild type mice. To examine the influence of sex on autophagy, mRNA and proteins were extracted from male and female mice tissues.The expressions of microtubule-associated protein 1 light chain 3 (LC3) and sequestosome 1 (p62), markers to monitor autophagy, were analyzed at 40, 60, 90, and 120 days of age.We found significant sex differences in the expression of LC3 and p62 in both tissues at these ages. The results indicated that sex and tissue specific differences exist in constitutive autophagy.These data underlined the need to include both sexes in the experimental groups to minimize any sex bias. 000057916 536__ $$9info:eu-repo/grantAgreement/ES/FIS/PI10-0178$$9info:eu-repo/grantAgreement/ES/MICINN/IPT-2011–1091-900000 000057916 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/ 000057916 590__ $$a1.579$$b2014 000057916 591__ $$aMEDICINE, RESEARCH & EXPERIMENTAL$$b85 / 123 = 0.691$$c2014$$dQ3$$eT3 000057916 591__ $$aBIOTECHNOLOGY & APPLIED MICROBIOLOGY$$b107 / 163 = 0.656$$c2014$$dQ3$$eT2 000057916 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion 000057916 700__ $$0(orcid)0000-0001-5193-7782$$aCalvo, A.C.$$uUniversidad de Zaragoza 000057916 700__ $$0(orcid)0000-0002-7477-8742$$aManzano, R. 000057916 700__ $$0(orcid)0000-0001-5740-0185$$aZaragoza, P.$$uUniversidad de Zaragoza 000057916 700__ $$0(orcid)0000-0001-5687-6704$$aOsta, R.$$uUniversidad de Zaragoza 000057916 7102_ $$11001$$2420$$aUniversidad de Zaragoza$$bDpto. Anatom.,Embri.Genét.Ani.$$cÁrea Genética 000057916 773__ $$g2014 (2014), 652817 [5 pp]$$pBioMed res. int.$$tBioMed Research International$$x2314-6133 000057916 8564_ $$s1603655$$uhttps://zaguan.unizar.es/record/57916/files/texto_completo.pdf$$yVersión publicada 000057916 8564_ $$s101791$$uhttps://zaguan.unizar.es/record/57916/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000057916 909CO $$ooai:zaguan.unizar.es:57916$$particulos$$pdriver 000057916 951__ $$a2020-10-23-13:53:01 000057916 980__ $$aARTICLE