000060606 001__ 60606
000060606 005__ 20200221144246.0
000060606 0247_ $$2doi$$a10.1016/j.diagmicrobio.2016.02.021
000060606 0248_ $$2sideral$$a94412
000060606 037__ $$aART-2016-94412
000060606 041__ $$aeng
000060606 100__ $$0(orcid)0000-0003-0920-8628$$aGonzález-Domínguez, Maria
000060606 245__ $$aGenotypic and phenotypic characterization of methicillin-resistant Staphylococcus aureus (MRSA) clones with high-level mupirocin resistance
000060606 260__ $$c2016
000060606 5060_ $$aAccess copy available to the general public$$fUnrestricted
000060606 5203_ $$aAn elevated proportion (27.2%) of high-level mupirocin-resistant methicillin-resistant Staphylococcus aureus (HLMUPR-MRSA) isolates were found in our environment in one year period. HLMUPR-MRSA isolates were mainly collected from skin and soft tissue samples, and diabetes was the main related comorbidity condition. These isolates were more frequently found in vascular surgery. HLMUPR-MRSA were more resistant to aminoglycosides than mupirocin-susceptible MRSA, linked to the presence of bifunctional and/or nucleotidyltransferase enzymes with/without macrolide resistance associated with the msr(A) gene. Most of HLMUPR-MRSA isolates belonged to ST125/t067. Nine IS257-ileS2 amplification patterns (p3 was the most frequent) were observed in HLMUPR-MRSA isolates, suggesting the presence of several mupirocin-resistance-carrying plasmids in our environment and promoting the emergence of mupirocin resistance. The presence of the same IS257-ileS2 amplification pattern p3 in 65% of HLMUPR-MRSA, all of them ST125/t067, suggests a clonal spread in our hospital and community environment which could explain the high prevalence of HLMUPR-MRSA during the study period. An outbreak situation or an increase in mupirocin consumption was not observed.
000060606 536__ $$9info:eu-repo/grantAgreement/ES/DGA/B24-211130
000060606 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000060606 590__ $$a2.401$$b2016
000060606 591__ $$aMICROBIOLOGY$$b64 / 124 = 0.516$$c2016$$dQ3$$eT2
000060606 591__ $$aINFECTIOUS DISEASES$$b47 / 84 = 0.56$$c2016$$dQ3$$eT2
000060606 592__ $$a1.237$$b2016
000060606 593__ $$aMedicine (miscellaneous)$$c2016$$dQ1
000060606 593__ $$aMicrobiology (medical)$$c2016$$dQ2
000060606 593__ $$aInfectious Diseases$$c2016$$dQ2
000060606 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000060606 700__ $$0(orcid)0000-0002-9742-1463$$aSeral, Cristina$$uUniversidad de Zaragoza
000060606 700__ $$aPotel, Carmen
000060606 700__ $$aSáenz, Yolanda
000060606 700__ $$aAlvarez, Maximiliano
000060606 700__ $$aTorres, Carmen
000060606 700__ $$0(orcid)0000-0002-2519-701X$$aCastillo, Francisco Javier$$uUniversidad de Zaragoza
000060606 7102_ $$11008$$2630$$aUniversidad de Zaragoza$$bDpto. Microb.Med.Pr.,Sal.Públ.$$cÁrea Microbiología
000060606 773__ $$g85 (2016), 213-217$$pDiagn. microbiol. infect. dis.$$tDiagnostic Microbiology and Infectious Disease$$x0732-8893
000060606 8564_ $$s355040$$uhttps://zaguan.unizar.es/record/60606/files/texto_completo.pdf$$yPostprint
000060606 8564_ $$s108370$$uhttps://zaguan.unizar.es/record/60606/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000060606 909CO $$ooai:zaguan.unizar.es:60606$$particulos$$pdriver
000060606 951__ $$a2020-02-21-13:25:24
000060606 980__ $$aARTICLE