Involvement of Cellular Prion Protein in a-Synuclein Transport in Neurons

Urrea, L. ; Segura-Feliu, M. ; Masuda-Suzukake, M. ; Hervera, A. ; Pedraz, L. ; Garcia Aznar, J.M. (Universidad de Zaragoza) ; Vila, M. ; Samitier, J. ; Torrents, E. ; Ferrer, I. ; Gavín, R. ; Hagesawa, M. ; Del Río, J.A.

Resumen: The cellular prion protein, encoded by the gene Prnp, has been reported to be a receptor of ß-amyloid. Their interaction is mandatory for neurotoxic effects of ß-amyloid oligomers. In this study, we aimed to explore whether the cellular prion protein participates in the spreading of a-synuclein. Results demonstrate that Prnp expression is not mandatory for a-synuclein spreading. However, although the pathological spreading of a-synuclein can take place in the absence of Prnp, a-synuclein expanded faster in PrPC-overexpressing mice. In addition, a-synuclein binds strongly on PrPC-expressing cells, suggesting a role in modulating the effect of a-synuclein fibrils.

Idioma: Inglés

DOI: 10.1007/s12035-017-0451-4

Año: 2017

Publicado en: MOLECULAR NEUROBIOLOGY (2017), 1-14
ISSN: 0893-7648

Factor impacto JCR: 5.076 (2017)

Categ. JCR: NEUROSCIENCES rank: 44 / 261 = 0.169 (2017) - Q1 - T1

Factor impacto SCIMAGO: 1.614 - Neurology (Q1) - Neuroscience (miscellaneous) (Q1) - Cellular and Molecular Neuroscience (Q2)

Financiación: info:eu-repo/grantAgreement/EUR/FP7/ERC2012-StG-306751
Financiación: info:eu-repo/grantAgreement/ES/MINECO/AGL2015-71764-REDT
Financiación: info:eu-repo/grantAgreement/ES/MINECO/BFU2015-67777-R
Financiación: info:eu-repo/grantAgreement/ES/MINECO/DPI2015-64221-C2-1-R

Tipo y forma: Artículo (Versión definitiva)

Área (Departamento): Área Mec.Med.Cont. y Teor.Est. (Dpto. Ingeniería Mecánica)