000060685 001__ 60685
000060685 005__ 20190709135458.0
000060685 0247_ $$2doi$$a10.1007/s12035-017-0451-4
000060685 0248_ $$2sideral$$a98253
000060685 037__ $$aART-2017-98253
000060685 041__ $$aeng
000060685 100__ $$aUrrea, L.
000060685 245__ $$aInvolvement of Cellular Prion Protein in a-Synuclein Transport in Neurons
000060685 260__ $$c2017
000060685 5060_ $$aAccess copy available to the general public$$fUnrestricted
000060685 5203_ $$aThe cellular prion protein, encoded by the gene Prnp, has been reported to be a receptor of ß-amyloid. Their interaction is mandatory for neurotoxic effects of ß-amyloid oligomers. In this study, we aimed to explore whether the cellular prion protein participates in the spreading of a-synuclein. Results demonstrate that Prnp expression is not mandatory for a-synuclein spreading. However, although the pathological spreading of a-synuclein can take place in the absence of Prnp, a-synuclein expanded faster in PrPC-overexpressing mice. In addition, a-synuclein binds strongly on PrPC-expressing cells, suggesting a role in modulating the effect of a-synuclein fibrils.
000060685 536__ $$9info:eu-repo/grantAgreement/EUR/FP7/ERC2012-StG-306751$$9info:eu-repo/grantAgreement/ES/MINECO/AGL2015-71764-REDT$$9info:eu-repo/grantAgreement/ES/MINECO/BFU2015-67777-R$$9info:eu-repo/grantAgreement/ES/MINECO/DPI2015-64221-C2-1-R
000060685 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000060685 590__ $$a5.076$$b2017
000060685 591__ $$aNEUROSCIENCES$$b44 / 261 = 0.169$$c2017$$dQ1$$eT1
000060685 592__ $$a1.614$$b2017
000060685 593__ $$aNeurology$$c2017$$dQ1
000060685 593__ $$aNeuroscience (miscellaneous)$$c2017$$dQ1
000060685 593__ $$aCellular and Molecular Neuroscience$$c2017$$dQ2
000060685 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000060685 700__ $$aSegura-Feliu, M.
000060685 700__ $$aMasuda-Suzukake, M.
000060685 700__ $$aHervera, A.
000060685 700__ $$aPedraz, L.
000060685 700__ $$0(orcid)0000-0002-9864-7683$$aGarcia Aznar, J.M.$$uUniversidad de Zaragoza
000060685 700__ $$aVila, M.
000060685 700__ $$aSamitier, J.
000060685 700__ $$aTorrents, E.
000060685 700__ $$aFerrer, I.
000060685 700__ $$aGavín, R.
000060685 700__ $$aHagesawa, M.
000060685 700__ $$aDel Río, J.A.
000060685 7102_ $$15004$$2605$$aUniversidad de Zaragoza$$bDpto. Ingeniería Mecánica$$cÁrea Mec.Med.Cont. y Teor.Est.
000060685 773__ $$g(2017), 1-14$$pMol. neurobiol.$$tMOLECULAR NEUROBIOLOGY$$x0893-7648
000060685 8564_ $$s18556218$$uhttps://zaguan.unizar.es/record/60685/files/texto_completo.pdf$$yVersión publicada
000060685 8564_ $$s82787$$uhttps://zaguan.unizar.es/record/60685/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000060685 909CO $$ooai:zaguan.unizar.es:60685$$particulos$$pdriver
000060685 951__ $$a2019-07-09-11:44:39
000060685 980__ $$aARTICLE