Página principal > Artículos > Synthesis of new pyrrolidine-based organocatalysts and study of their use in the asymmetric Michael addition of aldehydes to nitroolefins
Resumen: New pyrrolidine-based organocatalysts with a bulky substituent at C2 were synthesized from chiral imines derived from (R)-glyceraldehyde acetonide by diastereoselective allylation followed by a sequential hydrozirconation/iodination reaction. The new compounds were found to be effective organocatalysts for the Michael addition of aldehydes to nitroolefins and enantioselectivities up to 85% ee were achieved. Idioma: Inglés DOI: 10.3762/bjoc.13.59 Año: 2017 Publicado en: BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY 13 (2017), 612-619 ISSN: 1860-5397 Factor impacto JCR: 2.33 (2017) Categ. JCR: CHEMISTRY, ORGANIC rank: 25 / 57 = 0.439 (2017) - Q2 - T2 Factor impacto SCIMAGO: 0.929 - Organic Chemistry (Q1)