Toll-like receptor 2 modulates the inhibitory motor response induced by hydrogen sulphide in mouse colon

Forcén, R. ; Layunta, E. (Universidad de Zaragoza) ; Pardo, J. (Universidad de Zaragoza) ; Mesonero, J.E. (Universidad de Zaragoza) ; Grasa, L. (Universidad de Zaragoza)

Resumen: Introduction: The recognition of intestinal microbiota is in part carried out by toll-like receptors (TLR), which are responsible for initiating the innate immune response. Alterations in the intestinal microbiota and its recognition may contribute to the development of intestinal inflammatory pathologies. Otherwise, hydrogen sulphide (H2S) is an endogenous gaseous signalling molecule and it potentially plays a relevant role in the intestinal motility. In mammals, two pyridoxalphosphate-dependent enzymes are responsible for H2S synthesis: cystathionine b-synthase (CBS) and cystathionine -lyase (CSE)...

Idioma: Inglés

DOI: 10.1177/2050640616663688

Año: 2016

Publicado en: United European Gastroenterology Journal 4, Suppl. 1 (2016), S138-S139
ISSN: 2050-6406

Factor impacto JCR: 3.673 (2016)

Categ. JCR: GASTROENTEROLOGY & HEPATOLOGY rank: 21 / 79 = 0.266 (2016) - Q2 - T1

Factor impacto SCIMAGO: 1.137 - Oncology (Q2) - Gastroenterology (Q2)

Tipo y forma: Article (Published version)

Área (Departamento): Área Fisiología (Dpto. Farmacología y Fisiolog.)
Área (Departamento): Área Inmunología (Dpto. Microb.Med.Pr.,Sal.Públ.)