A multi-variate predictability framework to assess invasive cardiac activity and interactions during atrial fibrillation

Alcaine, Alejandro ; Masè, Michela ; Cristoforetti, Alessandro ; Ravelli, Flavia ; Nollo, Giandomenico ; Laguna, Pablo (Universidad de Zaragoza) ; Martinez, Juan Pablo (Universidad de Zaragoza) ; Faes, Luca

Resumen: Objective: This study introduces a predictability framework based on the concept of Granger causality (GC), in order to analyze the activity and interactions between different intracardiac sites during atrial fibrillation (AF). Methods: GC-based interactions were studied using a three-electrode analysis scheme with multi-variate autoregressive models of the involved preprocessed intracardiac signals. The method was evaluated in different scenarios covering simulations of complex atrial activity as well as endocardial signals acquired from patients. Results: The results illustrate the ability of the method to determine atrial rhythm complexity and to track and map propagation during AF. Conclusion: The proposed framework provides information on the underlying activation and regularity, does not require activation detection or postprocessing algorithms and is applicable for the analysis of any multielectrode catheter. Significance: The proposed framework can potentially help to guide catheter ablation interventions of AF.

Idioma: Inglés

DOI: 10.1109/TBME.2016.2592953

Año: 2017

Publicado en: IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING 64, 5 (2017), 1157-1168
ISSN: 0018-9294

Factor impacto JCR: 4.288 (2017)

Categ. JCR: ENGINEERING, BIOMEDICAL rank: 9 / 78 = 0.115 (2017) - Q1 - T1

Factor impacto SCIMAGO: 1.267 - Biomedical Engineering (Q1)

Financiación: info:eu-repo/grantAgreement/ES/DGA/T96
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/CIBER-BBN
Financiación: info:eu-repo/grantAgreement/ES/MINECO/BES-2011-046644
Financiación: info:eu-repo/grantAgreement/ES/MINECO/EEBB-I-14-08406
Financiación: info:eu-repo/grantAgreement/ES/MINECO/TEC2013-42140-R

Tipo y forma: Article (PostPrint)

Área (Departamento): Área Teoría Señal y Comunicac. (Dpto. Ingeniería Electrón.Com.)