Treatment of subclinical hyperthyroidism: Effect on body composition

Boj Carceller, D. ; Sanz París, A.. (Universidad de Zaragoza) ; Sánchez Oriz, E. (Universidad de Zaragoza) ; García-Foncillas López, R. (Universidad de Zaragoza) ; Calmarza Calmarza, P. ; Blay Cortes, V. (Universidad de Zaragoza) ; Abós Olivares, M.D. (Universidad de Zaragoza)
Treatment of subclinical hyperthyroidism: Effect on body composition
Resumen: Background: subclinical hyperthyroidism (SHT) is associated with harmful effects on cardiovascular system, bone metabolism and progression to clinical hyperthyroidism. Loss of weight is a common fact in patients with clinical hyperthyroidism and of particular relevance in elderly patients. Objective: to assess changes in body composition after radioiodine therapy for SHT due to toxic nodular goiter. Subjects and methods: prospective controlled cohort study. Patients with persistent SHT due to toxic nodular goiter were purposed to receive treatment with radioiodine (treatment group) or to delay treatment until the study was over (control group). All treated patients received 555 MBq of 131I. Body composition (lean mass, fat mass and bone mineral content) was determined by dual-energy X-ray absorptiometry (DEXA) at baseline and 12 months after. Results: twenty-nine patients were studied (age 69.5 ± 11.5; 75.9% women; BMI 27.1 ± 5.7 kg/m²; serum thyrotropin (TSH) 0.20 ± 0.21 µUI/mL; serum free thyroxine (T4) 1.01 ± 0.19 ng/dL), 17 belonging to the treatment group and 12 to the control group. Study groups were comparable, although there was a trend for the treatment group to have more fat mass. No longitudinal changes in body composition were noted in either group, except for a trend to gain fat mass. However, when individuals with age > 65 years were selected, only patients who received radioiodine therapy showed a significant increase in body weight (from 64.1 ± 10.0 to 66.9 ± 9.2 kg), BMI (from 27.3 ± 4.8 to 28.7 ± 4.5 kg/m²), fat mass (from 26.1 ± 8.5 to 27.8 ± 7.9 kg), lean mass (from 36.3 ± 0.4 to 37.4 ± 0.4 kg) and skeletal muscle mass index (SMI) (from 6.0 ± 0.6 to 6.3 ± 0.6 kg/m²). Conclusions: treatment of SHT has impact on body composition in subjects older than 65 years. Weight gain reflects increases in fat and, more interestingly, in lean mass.
Idioma: Inglés
DOI: 10.3305/nh.2015.32.5.9660
Año: 2015
Publicado en: NUTRICION HOSPITALARIA 32, 5 (2015), 2331-2337
ISSN: 0212-1611

Factor impacto JCR: 1.497 (2015)
Categ. JCR: NUTRITION & DIETETICS rank: 60 / 80 = 0.75 (2015) - Q3 - T3
Factor impacto SCIMAGO:

Tipo y forma: Article (Published version)
Área (Departamento): Área Radiol. y Medicina Física (Dpto. Pediatría Radiol.Med.Fís)
Área (Departamento): Area Medicina (Dpto. Medicina, Psiqu. y Derm.)
Área (Departamento): Área Medic.Prevent.Salud Públ. (Dpto. Microb.Med.Pr.,Sal.Públ.)

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