The role of purkinje automaticity as an arrhythmia mechanism in hyperkalaemia

Monasterio, Violeta ; Carro, Jesús ; Pueyo, Esther (Universidad de Zaragoza) ; Rodríguez, José F. (Universidad de Zaragoza)

Resumen: The pacemaker activity of Purkinje (PK) cells is usually suppressed by the sino-atrial (SA) node. Under abnormal conditions, PK cells may produce ectopic focal activity leading to tachycardia and fibrillation. This computational modelling work illustrates the potential role of PK automaticity as an arrhythmia mechanism in hyperkalaemia. First, we investigated the automaticity of isolated PK cells under hyperkalaemic conditions. Second, the potential consequences of altered PK automaticity were explored in a 1-D model of a terminal PK fibre running through a hyperkalaemic zone. Hyperkalaemia was found to accelerate the autorhythmic period of isolated PK cells with respect to control. For extracellular potassium levels = 7.2 mM, spontaneous action potentials (APs) appeared in the PK fibre, leading to conduction disturbances and complex combinations of spontaneous and stimulation-driven APs.

Idioma: Inglés

DOI: 10.1109/CIC.2015.7411050

Año: 2016

Publicado en: Computing in Cardiology 42 (2016), 873-876
ISSN: 2325-8861

Financiación: info:eu-repo/grantAgreement/ES/DGA/T88
Financiación: info:eu-repo/grantAgreement/ES/DGA/T96
Financiación: info:eu-repo/grantAgreement/ES/MINECO/TIN2012-37546-C03-03
Financiación: info:eu-repo/grantAgreement/ES/MINECO/TIN2013-41998-R

Tipo y forma: Congress (Published version)

Área (Departamento): Área Teoría Señal y Comunicac. (Dpto. Ingeniería Electrón.Com.)
Área (Departamento): Área Mec.Med.Cont. y Teor.Est. (Dpto. Ingeniería Mecánica)